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dc.contributor | Facultad de Ciencias de la Salud | es_ES |
dc.contributor.author | Vidán Estévez, Julia María | |
dc.contributor.author | Sánchez Herráez, Sergio | |
dc.contributor.author | Escalante Barrigón, Fernando | |
dc.contributor.author | Seco Calvo, Jesús Ángel | |
dc.contributor.other | Fisioterapia | es_ES |
dc.date | 2021-12-09 | |
dc.date.accessioned | 2024-01-16T09:39:53Z | |
dc.date.available | 2024-01-16T09:39:53Z | |
dc.identifier.citation | Vidán-Estévez, J., Sánchez-Herráez, S., Escalante-Barrigón, F., & Seco-Calvo, J. (2021). Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study. Journal of clinical medicine, 10(24), 5762. https://doi.org/10.3390/jcm10245762 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17623 | |
dc.description.abstract | [EN] Chronic non-healing wounds (CNHWs) may be associated with trauma or idiopathic in nature and are difficult to treat. Our objective was to assess the use of platelet-derived growth factor (PDGF) from single-donor platelets (al-PRP), using one freeze-thaw cycle, for treating CNHWs. We conducted a cross-sectional study. A total of 23 CNHWs being treated with al-PRP. The al-PRP treatment can be considered successful in well over half (n = 13, 56.5%) of the wounds. We found that all the wounds treated for up to 7 weeks showed partial or complete healing, while those treated for between 8 and 12 weeks did not show healing, healing again being successful in cases in which treatment was extended to more than 13 weeks (85.7%). Using chi-square tests, this relationship was found to be highly significant (p < 0.001, chi2 = 19.51; p value = 0.00006). Notably, Cramer’s V coefficient was very high (0.921), indicating that the effect size of PRP treatment duration on healing is very large (84.8%). We could suggest that the use of al-PRP in the healing of CNHWs is a promising approach. Further studies with larger sample sizes and long follow-ups are needed to obtain multivariate models to explain which factors favour the healing of ulcers treated with PRP | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.subject | Medicina. Salud | es_ES |
dc.subject.other | Al-PRP | es_ES |
dc.subject.other | Chronic non-healing wounds | es_ES |
dc.subject.other | Platelet-derived growth factor (PDGF) | es_ES |
dc.subject.other | Single Donor | es_ES |
dc.subject.other | One Freeze-Thaw Cycle | es_ES |
dc.title | Healing of Chronic Wounds with Platelet-Derived Growth Factors from Single Donor Platelet-Rich Plasma following One Freeze-Thaw Cycle. A Cross-Sectional Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/jcm10245762 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2077-0383 | |
dc.journal.title | Journal of Clinical Medicine | es_ES |
dc.volume.number | 10 | es_ES |
dc.issue.number | 24 | es_ES |
dc.page.initial | 5762 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
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