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Título
Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
npj Biofilms and Microbiomes
Número de la revista
1
Cita Bibliográfica
Peña-Cearra, A., Song, D., Castelo, J., Palacios, A., Lavín, J. L., Azkargorta, M., Elortza, F., Fuertes, M., Pascual-Itoiz, M. A., Barriales, D., Martín-Ruiz, I., Fullaondo, A., Aransay, A. M., Rodríguez, H., Palm, N. W., Anguita, J., & Abecia, L. (2023). Mitochondrial dysfunction promotes microbial composition that negatively impacts on ulcerative colitis development and progression. npj Biofilms and Microbiomes, 9(1). https://doi.org/10.1038/S41522-023-00443-Y
Editorial
Nature Research
Fecha
2023
Resumen
[EN] Recent evidence demonstrates potential links between mitochondrial dysfunction and inflammatory bowel diseases (IBD). In
addition, bidirectional interactions between the intestinal microbiota and host mitochondria may modulate intestinal inflammation.
We observed previously that mice deficient in the mitochondrial protein MCJ (Methylation-controlled J protein) exhibit increased
susceptibility to DSS colitis. However, it is unclear whether this phenotype is primarily driven by MCJ−/− associated gut microbiota
dysbiosis or by direct effects of MCJ-deficiency. Here, we demonstrate that fecal microbiota transplantation (FMT) from MCJdeficient into germ-free mice was sufficient to confer increased susceptibility to colitis. Therefore, an FMT experiment by cohousing
was designed to alter MCJ-deficient microbiota. The phenotype resulting from complex I deficiency was reverted by FMT. In
addition, we determined the protein expression pathways impacted by MCJ deficiency, providing insight into the pathophysiology
of IBD. Further, we used magnetic activated cell sorting (MACS) and 16S rRNA gene sequencing to characterize taxa-specific coating
of the intestinal microbiota with Immunoglobulin A (IgA-SEQ) in MCJ-deficient mice. We show that high IgA coating of fecal
bacteria observed in MCJ-deficient mice play a potential role in disease progression. This study allowed us to identify potential
microbial signatures in feces associated with complex I deficiency and disease progression. This research highlights the importance
of finding microbial biomarkers, which might serve as predictors, permitting the stratification of ulcerative colitis (UC) patients into
distinct clinical entities of the UC spectrum.
Materia
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Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/AEI/Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia/PID2021-124328OB-I00/ES/ GENERACION Y MODULACION DE LA RESPUESTA INMUNE ENTRENADA A LARGO PLAZO
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