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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Moroni, Barbara | |
dc.contributor.author | Granados Torres, José Enrique | |
dc.contributor.author | López Olvera, Jorge Ramón | |
dc.contributor.author | Espinosa Cerrato, José | |
dc.contributor.author | Ráez Bravo, Arián | |
dc.contributor.author | Mentaberre, Gregorio | |
dc.contributor.author | Fandos, Paulino | |
dc.contributor.author | Pazzi, Marco | |
dc.contributor.author | Romagnoli, Monica | |
dc.contributor.author | Gardini, Giulia | |
dc.contributor.author | Rossi, Luca | |
dc.contributor.author | Valldeperes, Marta | |
dc.contributor.author | Serrano, Emmanuel | |
dc.contributor.author | Ramos, Blanca | |
dc.contributor.author | Odore, Rosangela | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2022 | |
dc.date.accessioned | 2024-03-12T08:38:22Z | |
dc.date.available | 2024-03-12T08:38:22Z | |
dc.identifier.citation | Moroni, B., Granados Torres, J. E., López-Olvera, J. R., Espinosa Cerrato, J., Ráez Bravo, A., Mentaberre, G., Fandos, P., Pazzi, M., Romagnoli, M., Gardini, G., Rossi, L., Valldeperes, M., Serrano, E., Ramos, B., & Odore, R. (2022). Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study. Frontiers in Veterinary Science, 9. https://doi.org/10.3389/FVETS.2022.830157 | es_ES |
dc.identifier.other | https://www.frontiersin.org/articles/10.3389/fvets.2022.830157/full | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18802 | |
dc.description | Copyright © 2022 Moroni, Granados Torres, López-Olvera, Espinosa Cerrato, Ráez Bravo, Mentaberre, Fandos, Pazzi, Romagnoli, Gardini, Rossi, Valldeperes, Serrano, Ramos and Odore. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.description.abstract | [EN] Sarcoptic mange is considered the main driver of demographic declines occurred in the last decades in Iberian ibex (Capra pyrenaica) populations. Mass treatment campaigns by administration of in-feed acaricides are used as a measure to mitigate the impact of mange in the affected populations. However, there are no data on ivermectin (IVM) pharmacokinetics in this wild caprine, and the treatment through medicated feed is not endorsed by evidence on its effectiveness. The aim of this study is to determine the pharmacokinetic profile of IVM in plasma samples of ibexes after the experimental oral administration of IVM, using high performance liquid chromatography (HPLC) with automated solid phase extraction and fluorescence detection. A dose of 500 μg of IVM per body weight was orally administered in a feed bolus to nine healthy adult ibexes (seven males and two females). Blood samples were collected by jugular venipuncture into heparin-coated tubes at day 1, 2, 3, 4, 7, 10, 15, and 45 post-administration (dpa). The highest plasma concentration of IVM (Cmax = 3.4 ng/ml) was detected 24 h after the oral administration (T1), followed by a rapid decrease during the first week post-administration. Our results reveal that plasma IVM concentration drops drastically within 5 days of ingestion, questioning the effectiveness of a single in-feed dose of this drug to control sarcoptic mange. To the best of our knowledge, this is the first study on plasma availability of oral IVM in ibexes and in any wild ungulate species. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject.other | Ivermectin | es_ES |
dc.subject.other | Sarcoptic mange | es_ES |
dc.subject.other | Wildlife | es_ES |
dc.subject.other | Iberian ibex | es_ES |
dc.subject.other | Treatment | es_ES |
dc.subject.other | Medicated feed | es_ES |
dc.title | Ivermectin Plasma Concentration in Iberian Ibex (Capra pyrenaica) Following Oral Administration: A Pilot Study | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3389/FVETS.2022.830157 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Nacional de Investigación Fundamental/CGL2012-40043-C02-01/ES/EPIDEMIOLOGIA, INMUNOLOGIA Y PATOLOGIA DE LA SARNA SARCOPTICA EN LA CABRA MONTES// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Nacional de Investigación Fundamental/CGL2012-40043-C02- 02/ES/CARACTERIZACION DE LA INFESTACION EXPERIMENTAL POR SARCOPTES SCABIEI EN LA CABRA MONTES (CAPRA PYRENAICA)// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ Junta de Andalucía/Otras actuaciones de fomento de la I+D+I/RNM-118/ES/Biologia De Las Especies Cinegeticas Y Plagas// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2297-1769 | |
dc.journal.title | Frontiers in Veterinary Science | es_ES |
dc.volume.number | 9 | es_ES |
dc.page.initial | 830157 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.description.project | This project was funded by the Consejería de Medio Ambiente de la Junta de Andalucía (project 173/2009/M/00; 03/15/M/00; 861_11_M_00 and 2016/00014/M), and by the Spanish Ministerio de Economía y Competitividad (projects CGL2012-40043-C02-01, CGL2012-40043-C02- 02, and CGL2016-80543-P). The authors’ research activities are partially supported by the Plan Andaluz de Investigación (RNM118 group). MV is supported by a FI-GENCAT Fellowship (2020_FI_B2_00049, co-financiated by Agència de Gestió d’Ajuts Universitaris i de Recerca and European Social Fund) and ES by the Spanish Ministerio de Ciencia Innovación y Universidades (MICINN) through a Ramon y Cajal agreement (RYC-2016-21120). GM is a Serra Húnter Fellow. | es_ES |
dc.description.project | We are grateful to all the people involved in the experiment. Special thanks goes also to the park wardens and fieldworkers in the SNNS and, in particular, to José López, Isidro Puga, Apolo Sánchez, and Antonio Rodríguez for their professional and personal involvement in the study. | es_ES |
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