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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Argüello Rodríguez, Héctor | |
dc.contributor.author | Rodríguez Gómez, Irene Magdalena | |
dc.contributor.author | Sánchez Carvajal, José María | |
dc.contributor.author | Pallares, Francisco José | |
dc.contributor.author | Díaz, Iván | |
dc.contributor.author | Cabrera Rubio, Raúl | |
dc.contributor.author | Crispie, Fiona | |
dc.contributor.author | Cotter, Paul D. | |
dc.contributor.author | Mateu, Enric | |
dc.contributor.author | Martín Valls, Gerard | |
dc.contributor.author | Carrasco, Librado | |
dc.contributor.author | Gómez Laguna, Jaime | |
dc.contributor.other | Sanidad Animal | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-03-12T11:07:43Z | |
dc.date.available | 2024-03-12T11:07:43Z | |
dc.identifier.citation | Argüello, H., Rodríguez-Gómez, I. M., Sánchez-Carvajal, J. M., Pallares, F. J., Díaz, I., Cabrera-Rubio, R., Crispie, F., Cotter, P. D., Mateu, E., Martín-Valls, G., Carrasco, L., & Gómez-Laguna, J. (2022). Porcine reproductive and respiratory syndrome virus impacts on gut microbiome in a strain virulence-dependent fashion. Microbial Biotechnology, 15(3), 1007-1016. https://doi.org/10.1111/1751-7915.13757 | es_ES |
dc.identifier.issn | 1751-7915 | |
dc.identifier.other | https://enviromicro-journals.onlinelibrary.wiley.com/doi/epdf/10.1111/1751-7915.13757 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18829 | |
dc.description.abstract | [EN] Porcine reproductive and respiratory syndrome (PRRS) is a viral disease defined by reproductive problems, respiratory distress and a negative impact on growth rate and general condition. Virulent PRRS virus (PRRSV) strains have emerged in the last years with evident knowledge gaps in their impact on the host immune response. Thus, the present study examines the impact of acute PRRS virus (PRRSV) infection, with two strains of different virulence, on selected immune parameters and on the gut microbiota composition of infected pigs using 16S rRNA compositional sequencing. Pigs were infected with a low virulent (PRRS_3249) or a virulent (Lena) PRRSV-1 strain and euthanized at 1, 3, 6, 8 or 13 days post-inoculation (dpi). Faeces were collected from each animal at the necropsy time-point. Alpha and beta diversity analyses demonstrated that infection, particularly with the Lena strain, impacted the microbiome composition from 6 dpi onwards. Taxonomic differences revealed that infected pigs had higher abundance of Treponema and Methanobrevibacter (FDR < 0.05). Differences were more considerable for Lena- than for PRRS_3249-infected pigs, showing the impact of strain virulence in the intestinal changes. Lena-infected pigs had reduced abundancies of anaerobic commensals such as Roseburia, Anaerostipes, Butyricicoccus and Prevotella (P < 0.05). The depletion of these desirable commensals was significantly correlated to infection severity measured by viraemia, clinical signs, lung lesions and immune parameters (IL-6, IFN-γ and Hp serum levels). Altogether, the results from this study demonstrate the indirect impact of PRRSV infection on gut microbiome composition in a strain virulence-dependent fashion and its association with selected immune markers | es_ES |
dc.language | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nd/4.0/ | * |
dc.subject | Sanidad animal | es_ES |
dc.subject.other | Porcine reproductive and respiratory syndrome | es_ES |
dc.subject.other | PRRSV | es_ES |
dc.title | Porcine reproductive and respiratory syndrome virus impacts on gut microbiome in a strain virulence‐dependent fashion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1111/1751-7915.13757 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/ Programa Estatal de Promoción del Talento y su Empleabilidad/ RYC-2014-16735/ES/ RYC-2014-16735// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1751-7915 | |
dc.journal.title | Microbial Biotechnology | es_ES |
dc.volume.number | 15 | es_ES |
dc.issue.number | 3 | es_ES |
dc.page.initial | 1007 | es_ES |
dc.page.final | 1016 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.description.project | J. G omez-Laguna is supported by a ‘Ram on y Cajal’ contract of the Spanish Ministry of Economy and Competitiveness (RYC-2014-16735). Hector Arg€uello is supported by the ‘Beatriz Galindo’ Programme from the Spanish Ministry of Education (BEAGAL-18-106). This work was partially supported by the Spanish Ministry of Education and Science (AGL2016-76111-R). Research in the Cotter laboratory is funded by Science Foundation Ireland in the form of a centre grants (APC Microbiome Ireland, Grant Number SFI/12/RC/2273, and Vistamilk, Grant Number SFI/16/RC/3835) and by the European Commission under the Horizon 2020 programme under grant number 818368 (MASTER) | es_ES |
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