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Título
Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Animals
Número de la revista
5
Cita Bibliográfica
Blanco Vázquez, C., Balseiro, A., Alonso-Hearn, M., Juste, R. A., Iglesias, N., Canive, M., & Casais, R. (2021). Bovine intelectin 2 expression as a biomarker of paratuberculosis disease progression. Animals, 11(5). https://doi.org/10.3390/ANI11051370
Editorial
MDPI
Fecha
2021
Resumen
[EN]Paratuberculosis (PTB), a chronic granulomatous enteritis caused by Mycobacterium avium subsp. paratuberculosis (MAP), is responsible for important economic losses in the dairy indus-try. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) samples of animals with focal (log2 fold-change = 10.6) and diffuse (log2 fold-change = 6.8) PTB-associated lesions compared to animals without lesions. This study analyzes the potential use of ITLN2, a protein that has been described as fundamental in the innate immune response to infections, as a biomarker of MAP infection. The presence of ITLN2 was investigated by quantitative immunohistochemical analysis of ICV samples of 20 Holstein Friesian cows showing focal (n = 5), multifocal (n = 5), diffuse (n = 5) and no histological lesions (n = 5). Significant differences were observed in the mean number of ITLN2 immunostained goblet and Paneth cells between the three histopathological types and the control. The number of immunolabelled cells was higher in the focal histopathological type (116.9 ± 113.9) followed by the multifocal (108.7 ± 140.5), diffuse (76.5 ± 97.8) and control types (41.0 ± 81.3). These results validate ITLN2 as a post-mortem biomarker of disease progression.
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Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/RTA2014-00009-C02-02/ES/Marcadores inmunológicos y genéticos asociados a infecciones latentes o patentes causadas por Mycobacterium avium subsp. Paratuberculosis
- info:eu-repo/grantAgreement/ AEI/ Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/ RTI2018-094192-R-C22/ES/ DESARROLLO DE NUEVOS METODOS DE DIAGNOSTICO BASADOS EN BIOMARCADORES BOVINOS (PROTEINAS) PARA EL DIAGNOSTICO TEMPRANO DE LA PARATUBERCULOSIS BOVINA
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DOI
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