dc.contributor | Escuela de Ingenierias Industrial, Informática y Aeroespacial | es_ES |
dc.contributor.author | Farré, Núria | |
dc.contributor.author | Mojón, Diana | |
dc.contributor.author | Llagostera-Martín, Marc | |
dc.contributor.author | Belarte Tornero, Laia Carla | |
dc.contributor.author | Calvo-Fernández, Alicia | |
dc.contributor.author | Vallés, Ermengol | |
dc.contributor.author | Negrete, Alejandro | |
dc.contributor.author | García-Guimaraes, Marcos | |
dc.contributor.author | Bartolomé, Yolanda | |
dc.contributor.author | Fernández Llamas, Camino | |
dc.contributor.author | García-Durán, Ana B. | |
dc.contributor.author | Marrugat, Jaume | |
dc.contributor.author | Vaquerizo, Beatriz | |
dc.contributor.other | Ciencias de la Computacion e Inteligencia Artificial | es_ES |
dc.date | 2020-08-21 | |
dc.date.accessioned | 2024-03-19T12:55:30Z | |
dc.date.available | 2024-03-19T12:55:30Z | |
dc.identifier.citation | Farré, N., Mojón, D., Llagostera, M., Belarte-Tornero, L. C., Calvo-Fernández, A., Vallés, E., Negrete, A., García-Guimaraes, M., Bartolomé, Y., Fernández, C., García-Duran, A. B., Marrugat, J., and Vaquerizo, B. (2020). Prolonged qt interval in sars-cov-2 infection: Prevalence and prognosis. Journal of Clinical Medicine, 9(9), 1-15. https://doi.org/10.3390/JCM9092712 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/19085 | |
dc.description.abstract | [EN] Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection is
not well known. Objective: To determine whether the presence of a prolonged QT on admission is
an independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-center
cohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2,
recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients within
the first 48 h after diagnosis and before the administration of any medication with a known effect on
QT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval >480 milliseconds.
Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9.8%) had prolonged
QTc and only 3.2% had a baseline QTc > 500 milliseconds. Patients with prolonged QTc were older,
had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodes
of ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death was
higher in patients with prolonged QTc (41.0% vs. 8.7%, p < 0.001, multivariable HR 2.68 (1.58–4.55),
p < 0.001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTc
interval on admission. A prolonged QTc was independently associated with a higher mortality even
after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin.
An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Medicina. Salud | es_ES |
dc.subject.other | QT internal | es_ES |
dc.subject.other | COVID-19 | es_ES |
dc.subject.other | Hydroxychloroquine | es_ES |
dc.subject.other | Azithromycin | es_ES |
dc.subject.other | Prognosis | es_ES |
dc.subject.other | Death | es_ES |
dc.title | Prolonged QT Interval in SARS-CoV-2 Infection: Prevalence and Prognosis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/jcm9092712 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2077-0383 | |
dc.journal.title | Journal of Clinical Medicine | es_ES |
dc.volume.number | 9 | es_ES |
dc.issue.number | 9 | es_ES |
dc.page.initial | 2712 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3205 Medicina Interna | es_ES |
dc.subject.unesco | 3205.05 Enfermedades Infecciosas | es_ES |