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Título
Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
mAbs
Número de la revista
7
Cita Bibliográfica
Rodriguez Barbosa, Ferreras, Buhler, Jones, Schneider, Pérez Simón, & del Rio. (2018). Therapeutic implications of NK cell regulation of allogeneic CD8 T cell-mediated immune responses stimulated through the direct pathway of antigen presentation in transplantation. mAbs, 10(7), 1030-1044. https://doi.org/10.1080/19420862.2018.1502127
Editorial
Taylor and Francis Group
Fecha
2018
ISSN
1942-0862
Resumen
[EN]Natural killer (NK) cells are a population of innate type I lymphoid cells essential for early anti-viral responses and are known to modulate the course of humoral and cellular-mediated T cell responses. We assessed the role of NK cells in allogeneic CD8 T cell-mediated responses in an immunocompetent mouse model across an MHC class I histocompatibility barrier to determine its impact in therapeutic clinical interventions with polyclonal or monoclonal antibodies (mAbs) targeting lymphoid cells in transplantation. The administration of an NK cell depleting antibody to either CD8 T cell replete or CD8 T cell-depleted naïve C57BL/6 immunocompetent mice accelerated graft rejection. This accelerated rejection response was associated with an in vivo increased cytotoxic activity of CD8 T cells against bm1 allogeneic hematopoietic cells and bm1 skin allografts. These findings show that NK cells were impli-cated in the control host anti-donor cytotoxic responses, likely by competing for common cell growth factors in both CD8 T cell replete and CD8 T cell-depleted mice, the latter reconstituting in response to lymphopenia. Our data calls for precaution in solid organ transplantation under tolerogenic protocols involving extensive depletion of lymphocytes. These pharmacological biologics with depleting proper-ties over NK cells may accelerate graft rejection and promote aggressive CD8 T cell cytotoxic allore-sponses refractory to current immunosuppression.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/Junta de Castilla y León//LE093U13/ES/ESTUDIO DE LAS INTERACCIONES DE CD160 CON SU RECEPTOR HVEM EN UN MODELO PRECLÍNICO DE ALOREACTIVIDAD QUE MIMETIZA LA ENFERMEDAD DE INJERTO FRENTE A HUÉSPED EN TRASPLANTE
- info:eu-repo/grantAgreement/MINECO/Acción Estratégica de Salud/CP12/03063
- info:eu-repo/grantAgreement/ MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16/00002/ES/HVEM/BTLA/CD160 y PD-L1/PD1 como dianas inmunoterapéuticas en el tratamiento de tumores hematopoyéticos
- info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/CB16/12/00480/ES/CANCER
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