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Título
Hydrosoluble fiber (Plantago ovata husk) and levodopa I: Experimental study of the pharmacokinetic interaction
Autor
Facultad/Centro
Área de conocimiento
Cita Bibliográfica
European neuropsychopharmacology, 2005, n. 15
Editorial
Elsevier
Fecha
2005-01-11
Resumen
Fiber therapy could be used in patients with Parkinson disease to reduce the symptoms of gastrointestinal disorders; however, it could
interact with levodopa reducing its effectiveness. In this experimental study we have investigated whether the presence of Plantago ovata
husk (water-soluble fiber) modifies in rabbits the bioavailability and other pharmacokinetic parameters of levodopa (20 mg/kg) when
administered by the oral route at the same time. We have also studied whether pharmacokinetic modifications are fiber–dose dependent (100
and 400 mg/kg). The extent of levodopa absorbed when administering 100 mg/kg of fiber (AUC=43.4 Ag min ml 1) is approximately the
same as when levodopa is administered alone (AUC=47.1 Ag min ml 1); however, Cmax is lower (1.04 versus 1.43 Ag ml 1). Results
obtained indicate that fiber at the higher dose increases the extent of levodopa absorbed (AUC=62.2 Ag min ml 1), being the value of Cmax
similar (1.46 Ag ml 1). The value of tmax increases from 10 min when levodopa is administered alone to 20 min when the animals receive
fiber. On the other hand, since certain time on, levodopa concentrations are always higher in the groups that receive fiber: 60 min with 100
mg/kg fiber and 20 min with 400 mg/kg fiber. Fiber also increases the mean residence time (MRT). P. ovata husk administration with
levodopa could be beneficial, not only in patients with constipation, due to: lower adverse reactions (lower values of Cmax) and longer and
more stable effects (higher final concentrations and more time in the body).
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