Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array

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Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array

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Title: Detection and replication of QTL underlying resistance to gastrointestinal nematodes in adult sheep using the ovine 50K SNP array
Author: Atlija, Marina;Arranz, Juan-José;Martínez Valladares, María;Gutiérrez‑Gil, Beatriz
xmlui.dri2xhtml.METS-1.0.item-contributor: Facultad de Veterinaria
xmlui.dri2xhtml.METS-1.0.item-area: Producción Animal
Abstract: Persistence of gastrointestinal nematode (GIN) infection and the related control methods have major impacts on the sheep industry worldwide. Based on the information generated with the Illumina OvineSNP50 BeadChip (50 K chip), this study aims at confirming quantitative trait loci (QTL) that were previously identified by microsatellite ‑ based genome scans and identifying new QTL and allelic variants that are associated with indicator traits of parasite resistance in adult sheep. We used a commercial half ‑ sib population of 518 Spanish Churra ewes with available data for fecal egg counts (FEC) and serum levels of immunoglobulin A (IgA) to perform different genome scan QTL mapping analyses based on classical linkage analysis (LA), a combined linkage disequilibrium and linkage analysis (LDLA) and a genome ‑ wide association study (GWAS)
xmlui.dri2xhtml.METS-1.0.item-desfisica: 16 p.
xmlui.dri2xhtml.METS-1.0.item-peerreviewed: SI
Publisher: Institut National de la Recherche Agronomique (INRA)
xmlui.dri2xhtml.METS-1.0.item-citation: Genetics Selection Evolution, 2016, vol. 48, n. 4
URI: http://hdl.handle.net/10612/5017
Date: 2016-01-15
xmlui.dri2xhtml.METS-1.0.item-tipo: info:eu-repo/semantics/article
Subject: Producción animal
xmlui.dri2xhtml.METS-1.0.item-palclave: Nematodos
Ganado ovino
Gastrointestinal nematodes
xmlui.dri2xhtml.METS-1.0.item-projectID: info:eu-repo/grantAgreement/EC/FP7/264639
xmlui.dri2xhtml.METS-1.0.item-sponsorship: This work was supported by a competitive grant from the Castilla and León regional government (Junta de Castilla y León) (Ref. LE245A12-2) and the AGL2012-34437 project funded by the Spanish Ministry of Economy and Competitiveness (MINECO). M Atlija is a grateful grantee of a Marie Curie fellowship funded by the EC-funded Initial Training Network (ITN) NematodeSystemHealth (FP7-PEOPLE-2010-ITN Ref. 264639). B Gutiérrez-Gil is funded through the Spanish “Ramón y Cajal” Programme (RYC-2012-10230) from the MINECO.
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