RT info:eu-repo/semantics/article
T1 Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer's disease
A1 Bello-Corral, Laura
A1 Alves-Gomes, Lisa
A1 Fernández Fernández , Jesús Antonio
A1 Fernández García, Daniel
A1 Casado Verdejo, Inés
A1 Sánchez Valdeón, Leticia
A2 Enfermeria
K1 Enfermería
K1 Alzheimer's
K1 Gut microbiota
K1 Oral microbiota
K1 Dysbiosis
K1 Neuroinflammation
K1 NLRP3
AB [EN]  A diverse and stable microbiota promotes a healthy state, nevertheless, an imbalance in gut or oral bacterial composition, called dysbiosis, can cause gastrointestinal disorders, systemic inflammatory states and oxidative stress, among others. Recently, gut and oral dysbiosis has been linked to Alzheimer's disease (AD), which is considered the most common form of dementia and a public health priority due to its high prevalence and incidence. The aim of this review is to highlight the implications of gut and oral microbiota in the neuroinflammation characteristic of AD pathology and the subsequent cognitive impairment. It is a systematic review of the current literature obtained by searching the PubMed, Web of Science and Scopus databases. The characteristic intestinal dysbiosis in AD patients leads to increased permeability of the intestinal barrier and activates immune cells in the central nervous system due to translocation of microbiota-derived metabolites and/or bacteria into the circulation leading to increased neuroinflammation and neuronal loss, thus generating the cognitive impairment characteristic of AD. The presence in the central nervous system of Porphyromonas gingivalis can cause an increased neuroinflammation and beta-amyloid peptide accumulation.
PB Elsevier
SN 0024-3205
LK https://hdl.handle.net/10612/17288
UL https://hdl.handle.net/10612/17288
NO Bello-Corral, L., Alves-Gomes, L., Fernández-Fernández, J. A., Fernández-García, D., Casado-Verdejo, I., & Sánchez-Valdeón, L. (2023). Implications of gut and oral microbiota in neuroinflammatory responses in Alzheimer’s disease. Life Sciences, 333(122132), 122132. https://doi.org/10.1016/j.lfs.2023.122132
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 19-may-2024