RT info:eu-repo/semantics/article
T1 Bioluminescent Imaging Identifies Thymus, As Overlooked Colonized Organ, in a Chronic Model of Leishmania donovani Mouse Visceral Leishmaniasis
A1 Domínguez Asenjo, Bárbara
A1 Gutiérrez Corbo, María del Camino
A1 Pérez Pertejo, Maria Yolanda
A1 Iborra, Salvador
A1 Balaña Fouce, Rafael
A1 Reguera Torres, Rosa María
A2 Toxicologia
K1 Medicina. Salud
K1 Leishmania donovani
K1 Drug discovery
K1 In vivo imaging
K1 Thymus
K1 32 Ciencias Médicas
K1 3109 Ciencias Veterinarias
K1 3214 Toxicología
AB [EN] The search for new drugs against neglected parasitic diseases has experienced a major boost in recent years with the incorporation of bioimaging techniques. Visceral leishmaniasis, the second more neglected disease in the world, has effective treatments but with several disadvantages that make the search for new therapeutic solutions an urgent task. Animal models of visceral leishmaniasis that resemble the human disease have the disadvantage of using hamsters, which are an outbred breeding animal too large to obtain acceptable images with current bioimaging methodologies. Mouse models of visceral leishmaniasis seem, however, to be more suitable for early (acute) stages of the disease, but not for chronic ones. In our work, we describe a chronic Balb/c mouse model in which the infection primarily colonizes the spleen and well recreates the late stages of human disease. Thanks to the bioluminescent image, we have been able to identify experimentally, for the first time, a new primary lymphoid organ of colonization, the thymus, which appears infected from the beginning until the late phases of the infection.
PB ACS Publications
SN 2373-8227
LK https://hdl.handle.net/10612/17832
UL https://hdl.handle.net/10612/17832
NO Domínguez-Asenjo, B., Gutiérrez-Corbo, C., Pérez-Pertejo, Y., Iborra, S., Balaña-Fouce, R., & Reguera, R. M. (2021). Bioluminescent Imaging Identifies Thymus, As Overlooked Colonized Organ, in a Chronic Model of Leishmania donovani Mouse Visceral Leishmaniasis. ACS infectious diseases, 7(4), 871–883. https://doi.org/10.1021/acsinfecdis.0c00864
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 03-jun-2024