RT info:eu-repo/semantics/article
T1 Protective Effect of Oral BCG and Inactivated Mycobacterium bovis Vaccines in European Badgers (Meles meles) Experimentally Infected With M. bovis
A1 Balseiro Morales, Ana María
A1 Prieto, José Miguel
A1 Álvarez, Vega
A1 Lesellier, Sandrine
A1 Dave, Dipesh
A1 Salguero, Francisco Javier
A1 Sevilla, Iker A.
A1 Infantes-Lorenzo, José Antonio
A1 Garrido, Joseba M.
A1 Adriaensen, Hans
A1 Juste, Ramón A.
A1 Barral, Marta
A2 Sanidad Animal
K1 Sanidad animal
K1 BCG vaccine
K1 Mycobacterium bovis heat-inactivated (HIMB) vaccine
K1 Badger
K1 Efficacy
K1 Tuberculosis
K1 3109 Ciencias Veterinarias
AB [EN] In Europe, badgers (Meles meles) are recognized as major tuberculosis (TB) reservoir hosts with the potential to transmit infection to associated cattle herds. Recent studies in Spain have demonstrated that vaccination with a heat-inactivated Mycobacterium bovis vaccine (HIMB) successfully protects captive wild boar and red deer against progressive disease. The aim of this study was to evaluate the efficacy of two oral vaccines against TB in a badger model: the live-attenuated M. bovis bacillus Calmette-Guérin BCG vaccine (Danish strain) and a HIMB vaccine. Twenty-four badgers were separated in three treatment groups: oral vaccinated with live BCG (108 CFU, n = 5), oral vaccinated with HIMB (107 CFU, n = 7), and unvaccinated controls (n = 12). All badgers were experimentally infected with M. bovis (103 CFU) by the endobronchial route targeting the right middle lung lobe. Throughout the study, clinical, immunological, pathological, and bacteriological parameters of infection were measured. Both vaccines conferred protection against experimental TB in badger, as measured by a reduction of the severity and lesion volumes. Based on these data, HIMB vaccination appears to be a promising TB oral vaccine candidate for badgers in endemic countries.
PB Frontiers
LK https://hdl.handle.net/10612/17876
UL https://hdl.handle.net/10612/17876
NO Balseiro, A., Prieto, J. M., Álvarez, V., Lesellier, S., Davé, D., Salguero, F. J., Sevilla, I. A., Infantes-Lorenzo, J. A., Garrido, J. M., Adriaensen, H., Juste, R. A., & Barral, M. (2020). Protective Effect of Oral BCG and Inactivated Mycobacterium bovis Vaccines in European Badgers (Meles meles) Experimentally Infected With M. bovis. Frontiers in Veterinary Science, 7. https://doi.org/10.3389/FVETS.2020.00041
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 02-jun-2024