RT info:eu-repo/semantics/article
T1 Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi
A1 Proctor, Robert Henry
A1 McCormick, Susan P.
A1 Kim, Hye-Seon
A1 Cardoza, Rosa E.
A1 Stanley, April M.
A1 Lindo Yugueros, Laura
A1 Kelly, Amy
A1 Brown, Daren W.
A1 Lee, Theresa
A1 Vaughan, Martha Marie
A1 Alexander, Nancy J.
A1 Busman, Mark
A1 Gutiérrez Martín, Santiago
A2 Microbiologia
K1 Biología
K1 Bioquímica
K1 Trichothecene
K1 Toxins
K1 Plant pathogenic
K1 Entomopathogenic fungi
AB [EN] Trichothecenes are a family of terpenoid toxins produced by multiple genera of fungi, including plant and insect pathogens. Some trichothecenes produced by the fungus Fusarium are among the mycotoxins of greatest concern to food and feed safety because of their toxicity and frequent occurrence in cereal crops, and trichothecene production contributes to pathogenesis of some Fusarium species on plants. Collectively, fungi produce over 150 trichothecene analogs: i.e., molecules that share the same core structure but differ in patterns of substituents attached to the core structure. Here, we carried out genomic, phylogenetic, gene-function, and analytical chemistry studies of strains from nine fungal genera to identify genetic variation responsible for trichothecene structural diversity and to gain insight into evolutionary processes that have contributed to the variation. The results indicate that structural diversity has resulted from gain, loss, and functional changes of trichothecene biosynthetic (TRI) genes. The results also indicate that the presence of some substituents has arisen independently in different fungi by gain of different genes with the same function. Variation in TRI gene duplication and number of TRI loci was also observed among the fungi examined, but there was no evidence that such genetic differences have contributed to trichothecene structural variation. We also inferred ancestral states of the TRI cluster and trichothecene biosynthetic pathway, and proposed scenarios for changes in trichothecene structures during divergence of TRI cluster homologs. Together, our findings provide insight into evolutionary processes responsible for structural diversification of toxins produced by pathogenic fungi
PB Public Library of Science
LK https://hdl.handle.net/10612/19103
UL https://hdl.handle.net/10612/19103
NO Proctor, R. H., McCormick, S. P., Kim, H.-S., Cardoza, R. E., Stanley, A. M., Lindo, L., Kelly, A., Brown, D. W., Lee, T., Vaughan, M. M., Alexander, N. J., Busman, M., & Gutiérrez. (2018). Evolution of structural diversity of trichothecenes, a family of toxins produced by plant pathogenic and entomopathogenic fungi. PLoS Pathogens, 14(4). https://doi.org/10.1371/JOURNAL.PPAT.1006946
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 20-may-2024