RT info:eu-repo/semantics/article
T1 Genetic Characterization and Phylogenetic Analysis of Small Ruminant Lentiviruses Detected in Spanish Assaf Sheep with Different Mammary Lesions
A1 Gayo Roces, Elena
A1 Cuteri, Vincenzo
A1 Polledo, Laura
A1 Rossi, Giacomo
A1 García Marín, Juan Francisco
A1 Preziuso, S.
A2 Sanidad Animal
K1 Sanidad animal
K1 Veterinaria
K1 Sheep
K1 Small Ruminant Lentivirus
K1 Genetic characterization
K1 Udder
K1 Histopathology
K1 3109 Ciencias Veterinarias
K1 3104.07 Ovinos
AB [EN]Small Ruminant Lentiviruses (SRLVs) are widespread in many countries and cause economically relevant, slow, and persistent diseases in sheep and goats. Monitoring the genetic diversity of SRLVs is useful to improve the diagnostic tools used in the eradication programs. In this study, SRLVs detected in Spanish Assaf sheep with different grades of lymphoproliferative mastitis were sequenced. Genetic characterization showed that most samples belonged to type A and were closer to Spanish SRLV isolates previously classified as A2/A3. Four samples belonged to subtype B2 and showed higher homology with Italian B2 strains than with Spanish B2 isolates. Amino acid sequences of immuno-dominant epitopes in the gag region were very conserved while more alterations were found in the LTR sequences. No significant correlations were found between grades of mastitis and alterations in the sequences although samples with similar histological features were phylogenetically closer to each other. Broader genetic characterization surveys in samples with different grades of SRLV-lesions are required for evaluating potential correlations between SRLV sequences and the severity of diseases.
PB MDPI
LK https://hdl.handle.net/10612/19445
UL https://hdl.handle.net/10612/19445
NO Gayo, E., Cuteri, V., Polledo, L., Rossi, G., García Marín, J. F., & Preziuso, S. (2018). Genetic characterization and phylogenetic analysis of small ruminant lentiviruses detected in Spanish Assaf sheep with different mammary lesions. Viruses, 10(6), Article e315. https://doi.org/10.3390/V10060315
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 10-jun-2024