RT info:eu-repo/semantics/article
T1 Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbits
A1 González, Aranzazu
A1 Fernández, Nélida
A1 Sahagún , Ana M.
A1 García, Juan J.
A1 Diez Liébana, María José
A1 Castro, Luis J.
A1 Sierra Vega, Matilde
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Ethinyl estradiol
K1 Glucomannan
K1 Rabbits
K1 Fiber
K1 Pharmacokinetics
K1 Oral absorption
K1 Ratones
AB To the beneficial properties of dietary fiber in human health, several disadvantages can be added as the possible modification of thebioavailability of other drugs when administered by the oral route. In this study, the influence of glucomannan in the oral bioavailability ofethinyl estradiol (EE), when administered to female rabbits in two different dosage forms (enteric capsules and dispersed in water), wasestablished. To carry out the study, three groups of six animals each were used. All animals received 1 mg kg 1 oral EE, and rabbits in groups2 and 3 received 1.5 g glucomannan dispersed in water or in enteric capsules, respectively, immediately before EE. When comparing theresults obtained after the administration of EE/glucomannan dispersed in water with those obtained after the administration of this estrogenwithout fiber, we can see that Cmax is 1.4 times lower, AUC 1.9 times lower and that tmax is identical (10 min). However, after theadministration of fiber in enteric capsules, AUC and Cmax are higher (4.1 and 7.8 times, respectively) than when the estrogen wasadministered alone, and also, there is a delay in tmax (20 min). After the administration of glucomannan in the enteric capsule, the fiber forms,as in the stomach, a highly viscous solution in the gut that would limit EE access to the mucosal surface delaying its absorption. However,this effect could be compensated by a reduction of EE metabolism in the intestinal wall, leading to a higher absorption of the estrogen.
PB ARHP
YR 2015
FD 2015-07-31
LK http://hdl.handle.net/10612/4476
UL http://hdl.handle.net/10612/4476
NO Contraception, 2004, n. 70
NO P. 423-427
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 06-may-2024