The pharmacokinetics and metabolism of ivermectin in domestic animal species

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The pharmacokinetics and metabolism of ivermectin in domestic animal species

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Title: The pharmacokinetics and metabolism of ivermectin in domestic animal species
Author: González, Aranzazu;Sahagún, Ana M.;Diez, M. José;Fernández, Nélida;Sierra, Matilde;García, Juan J.
xmlui.dri2xhtml.METS-1.0.item-contributor: Facultad de Veterinaria
xmlui.dri2xhtml.METS-1.0.item-area: Farmacologia
Abstract: The pharmacokinetic properties of drugs are closely related to their pharmacological efficacy. The kinetics of ivermectin are characterised, in general terms, by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The kinetics vary according to the route of administration, formulation, animal species, body condition, age, and physiological status, all of which contribute to differences in drug efficacy. Characterisation of ivermectin kinetics can be used to predict and optimise the value of the parasiticide effects and to design programmes for parasite control. This article reviews the pharmacokinetics of ivermectin in several domestic animal species.
xmlui.dri2xhtml.METS-1.0.item-desfisica: P. 25-37
xmlui.dri2xhtml.METS-1.0.item-peerreviewed: SI
Publisher: Elsevier
xmlui.dri2xhtml.METS-1.0.item-citation: The Veterinary Journal, 2009, n. 179
URI: http://hdl.handle.net/10612/4527
Date: 2009-07-17
xmlui.dri2xhtml.METS-1.0.item-tipo: info:eu-repo/semantics/article
Subject: Ecología. Medio ambiente
Farmacología
Zoología
xmlui.dri2xhtml.METS-1.0.item-palclave: Ivermectin
Pharmacokinetics
Animal species
Absorption
Distribution
Metabolism
Excretion
Cattle
Sheep
Goat
Pig
Dog
Review
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