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Título
Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Journal of Cellular Physiology
Número de la revista
7
Datos de la obra
San-Miguel, B., Fernández-Palanca, P., Mauriz, J. L., Tuñón, M. J., & González-Gallego, J. (2022). Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence [Review of Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence]. Journal of Cellular Physiology, 237(7), 2740-2757. John Wiley and Sons Inc. https://doi.org/10.1002/JCP.30735
Editor
Wiley-Blackwell
Fecha
2022
ISSN
0021-9541
Resumo
[EN] Hepatic fibrosis is a reversible response to either acute or chronic cellular injury froma wide variety of etiologies, characterized by excessive deposition of extracellularmatrix resulting in liver dysfunction and cirrhosis. Melatonin (N‐acetyl‐5‐methoxytryptamine), the main product secreted by the pineal gland, is a multitaskingindolamine with important physiological functions such as anti‐inflammatory andantioxidant actions, modulation of circadian rhythms, and immune system enhance-ment. Among the numerous biological activities of melatonin, its antifibrotic effectshave received increasingly more attention. In this study, we performed a systematicreview of publications of the last 10 years evaluating the mechanisms of action ofmelatonin against liver fibrosis. The study protocol was registered at PROSPERO(CRD42022304744). Literature research was performed employing PubMed,Scopus, and Web of Science (WOS) databases, and after screening, 29 articleswere included. Results from the selected studies provided denoted the usefulactions of melatonin on the development, progression, and evolution of liver fibrosis.Melatonin antifibrotic effects in the liver involved the reduction of profibrogenicmarkers and modulation of several cellular processes and molecular pathways,mainly acting as an antioxidant and anti‐inflammatory agent. In addition, theindolamine influenced different molecular processes, such as hepatocyte apoptosis,modulation of autophagy and mitophagy, restoration of circadian rhythms, andmodulation of microRNAs, among others. Although some limitations have beenfound regarding variability in the study design, the findings here summarized displaythe potential role of melatonin in ameliorating the development of liver fibrosis andits possible progression to liver cirrhosis and hepatocarcinoma
Materia
Palabras clave
Peer review
SI
ID proyecto
- Junta de Castilla y León LE017P20
- info:eu-repo/grantAgreement/MCIN/AEI/10.13039/501100011033
URI
DOI
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