dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Fernández Riesco, Marta | |
dc.contributor.author | García Valcarce, David | |
dc.contributor.author | Sellés Egea, Alba | |
dc.contributor.author | Esteve Codina, Anna | |
dc.contributor.author | Herráez Ortega, María Paz | |
dc.contributor.author | Robles Rodríguez, Vanesa | |
dc.contributor.other | Bioquimica y Biologia Molecular | es_ES |
dc.date | 2023 | |
dc.date.accessioned | 2023-12-13T07:59:13Z | |
dc.date.available | 2023-12-13T07:59:13Z | |
dc.identifier.citation | Riesco, M. F., Valcarce, D. G., Sellés-Egea, A., Esteve-Codina, A., Herráez, M. P., & Robles, V. (2023). miR-29a Is Downregulated in Progenies Derived from Chronically Stressed Males. International journal of molecular sciences, 24(18), 14107. https://doi.org/10.3390/ijms241814107 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17465 | |
dc.description | El artículo pertenece al special issue Ovary and Testis: Molecular Biological Insights | es_ES |
dc.description.abstract | [EN] Recent research has provided compelling evidence demonstrating that paternal exposure
to different stressors can influence their offspring’s phenotypes. We hypothesized that paternal stress
can negatively impact the progeny, altering different miRs and triggering different physiological
alterations that could compromise offspring development. To investigate this, we exposed zebrafish
male siblings to a chronic stress protocol for 21 days. We performed RNA-sequencing (RNA-seq)
analyses to identify differentially expressed small noncoding RNAs in 7-day postfertilization (dpf)
larvae derived from paternally stressed males crossed with control females compared with the control
progeny. We found a single miRNA differentially expressed—miR-29a—which was validated in
larva and was also tested in the sperm, testicles, and brain of the stressed progenitors. We observed
a vertical transmission of chronic stress to the unexposed larvae, reporting novel consequences of
paternally inherited chronic stress at a molecular level. The deregulation of mi-R29a in those larvae
could affect relevant biological processes affecting development, morphogenesis, or neurogenesis,
among others. Additionally, these disruptions were associated with reduced rates of survival and
hatching in the affected offspring. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Biología | es_ES |
dc.subject.other | Chronic stress | es_ES |
dc.subject.other | Offspring | es_ES |
dc.subject.other | RNA-seq | es_ES |
dc.subject.other | Small-RNAs | es_ES |
dc.subject.other | Behavior | es_ES |
dc.subject.other | Hatching rates | es_ES |
dc.subject.other | Survival | es_ES |
dc.subject.other | Malformations | es_ES |
dc.title | miR-29a is downregulated in progenies derived from chronically stressed males | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/ijms241814107 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/ Programa Estatal de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i/ PID2019-108509RB-I00/ES/ EL ESTRES EN LA REPRODUCCION DE PECES: TRANSMISION DE LOS EFECTOS NEGATIVOS A LA PROGENIE Y DESARROLLO DE NUEVAS TECNOLOGIAS PARA REVERTIRLOS | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1422-0067 | |
dc.journal.title | International Journal of Molecular Sciences | es_ES |
dc.volume.number | 24 | es_ES |
dc.issue.number | 18 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2415 Biología Molecular | es_ES |
dc.description.project | This research was funded by grant PID2019-108509RB-I00-MCIN/AEI/10.13039/501100011033. D.G.V. was funded by grant IJC2020-044091-I-MCIN/AEI/10.13039/501100011033. A.E.-C. is funded by ISCIII /MINECO (PT17/0009/0019) and cofunded by FEDER | es_ES |