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Título
Effect of low sperm quality on progeny: a study on zebrafish as model species
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Scientific Reports
Cita Bibliográfica
Riesco, M., Valcarce, D., Martínez Vázquez, J., Robles, V. (2019). Effect of low sperm quality on progeny: a study on zebrafish as model species. Scientific Reports. 9. 10.1038/s41598-019-47702-7
Editorial
Springer
Fecha
2019
Resumen
[EN] Nowadays a decrease tendency in human sperm quality has been reported mainly in developed
countries. Reproductive technologies have been very valuable in achieving successful pregnancies
with low quality sperm samples. However, considering that spermatozoa molecular contribution is
increasingly important in recent studies, it is crucial to study whether fertilization with low sperm
quality could leave a molecular mark on progeny. This study explores the consequences that fertilization
with low sperm quality may have on progeny, using zebrafish as a model. Good and bad breeders were
established attending to sperm quality analyses and were individually tracked. Significant differences
in fertilization and malformation rates were obtained in progenies between high and low quality
sperm samples. Moreover an altered miR profile was found in the progenies of bad zebrafish breeders
(upregulation of miR-141 and miR -122 in 24 hpf embryos) and as a consequence, some of their targets
involved in male sex development such as dmrt1, suffered downregulation. Our results indicate
that fertilizing with high sperm quality samples becomes relevant from a new perspective: to avoid
molecular alterations in the progeny that could remain masked and therefore produce unexpected
consequences in it.
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/MINECO/ Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/ AGL2015-68330-C2-1-R/ES/ MECANISMOS MOLECULARES SUBYACENTES AL FALLO REPRODUCTIVO EN SOLEA SENEGALENSIS: DESARROLLO DE NUEVAS ESTRATEGIAS Y TRATAMIENTOS PARA SOLVENTAR LA DISFUNCION REPRODUTIVA EN F1
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