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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Quiroga, Rocío | |
dc.contributor.author | Nistal González, Maria Esther | |
dc.contributor.author | Estébanez González, Brisamar | |
dc.contributor.author | Juárez‐Fernández, María | |
dc.contributor.author | Martínez Flórez, Susana | |
dc.contributor.author | García Mediavilla, María Victoria | |
dc.contributor.author | Paz Fernández, José Antonio de | |
dc.contributor.author | González Gallego, Javier | |
dc.contributor.author | Sánchez Campos, Sonia | |
dc.contributor.author | Cuevas González, María José | |
dc.contributor.author | Porras Sanabria, David | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2020-07 | |
dc.date.accessioned | 2024-01-18T09:49:47Z | |
dc.date.available | 2024-01-18T09:49:47Z | |
dc.identifier.citation | Quiroga, R., Nistal González, E., Estébanez, B., Porras, D., Juárez-Fernández, M., Martínez-Flórez, S., García-Mediavilla, M. V., de Paz, J. A., González-Gallego, J., Sánchez-Campos, S., & Cuevas, M. J. (2020). Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children. Experimental and Molecular Medicine, 52(7), 1048-1061. https://doi.org/10.1038/S12276-020-0459-0 | es_ES |
dc.identifier.issn | 1226-3613 | |
dc.identifier.uri | https://hdl.handle.net/10612/17663 | |
dc.description.abstract | [EN] Childhood obesity has reached epidemic levels and is a serious health concern associated with metabolic syndrome, nonalcoholic fatty liver disease, and gut microbiota alterations. Physical exercise is known to counteract obesity progression and modulate the gut microbiota composition. This study aims to determine the effect of a 12-week strength and endurance combined training program on gut microbiota and inflammation in obese pediatric patients. Thirty-nine obese children were assigned randomly to the control or training group. Anthropometric and biochemical parameters, muscular strength, and inflammatory signaling pathways in mononuclear cells were evaluated. Bacterial composition and functionality were determined by massive sequencing and metabolomic analysis. Exercise reduced plasma glucose levels and increased dynamic strength in the upper and lower extremities compared with the obese control group. Metagenomic analysis revealed a bacterial composition associated with obesity, showing changes at the phylum, class, and genus levels. Exercise counteracted this profile, significantly reducing the Proteobacteria phylum and Gammaproteobacteria class. Moreover, physical activity tended to increase some genera, such as Blautia, Dialister, and Roseburia, leading to a microbiota profile similar to that of healthy children. Metabolomic analysis revealed changes in short-chain fatty acids, branched-chain amino acids, and several sugars in response to exercise, in correlation with a specific microbiota profile. Finally, the training protocol significantly inhibited the activation of the obesity-associated NLRP3 signaling pathway. Our data suggest the existence of an obesity-related deleterious microbiota profile that is positively modified by physical activity intervention. Exercise training could be considered an efficient nonpharmacological therapy, reducing inflammatory signaling pathways induced by obesity in children via microbiota modulation. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | Obesidad en niños | es_ES |
dc.subject.other | Ejercicio físico | es_ES |
dc.subject.other | microbiota | es_ES |
dc.title | Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1038/s12276-020-0459-0 | |
dc.relation.projectID | info:eu-repo/grantAgreement/ AEI / Programa Estatal de I+D+i Orientada a los Retos de la Sociedad / BFU2017-87960-R /ES/ EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD / | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2092-6413 | |
dc.journal.title | Experimental & Molecular Medicine | es_ES |
dc.volume.number | 52 | es_ES |
dc.issue.number | 7 | es_ES |
dc.page.initial | 1048 | es_ES |
dc.page.final | 1061 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3205.02 Endocrinología | es_ES |
dc.subject.unesco | 32 Ciencias Médicas | es_ES |
dc.description.project | This work was supported by grants from Ministerio de Economía, Industria y Competitividad (BFU2017–87960-R), Junta de Castilla y León and the European Regional Development Fund (FEDER) (LE063U16 and GRS1888/A/18). CIBERehd is funded by the Instituto de Salud Carlos III, Spain. B.E and M.J.F were supported by a fellowship from Ministerio de Educación (FPU15/05051 and FPU18/06257). E.N. was supported by Fundación de Investigación Sanitaria of León. D.P. was supported by a fellowship from Junta de Castilla y León, cofinanced by the European Social Fund. | es_ES |
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