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Título
The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Antioxidants
Número de la revista
12
Cita Bibliográfica
Juárez-Fernández, M., Porras, D., Petrov, P., Román-Sagüillo, S., García-Mediavilla, M. V., Soluyanova, P., Martínez-Flórez, S., González-Gallego, J., Nistal González, E., Jover, R., & Sánchez-Campos, S. (2021). The synbiotic combination of akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants, 10(12). https://doi.org/10.3390/ANTIOX10122001
Editorial
Basel: MDPI AG
Fecha
2021
Resumen
[EN] Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so
synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention together
with the administration of the bacteria Akkermansia muciniphila and the antioxidant quercetin in
an in vivo model of early obesity and NAFLD. 21-day-old rats were fed with control or high-fat
diet for six weeks. Then, all animals received control diet supplemented with/without quercetin
and/or A. muciniphila for three weeks. Gut microbiota, NAFLD-related parameters, circulating
bile acids (BAs) and liver gene expression were analyzed. The colonization with A. muciniphila
was associated with less body fat, while synbiotic treatment caused a steatosis remission, linked to
hepatic lipogenesis modulation. The synbiotic promoted higher abundance of Cyanobacteria and
Oscillospira, and lower levels of Actinobacteria, Lactococcus, Lactobacillus and Roseburia. Moreover, it
favored elevated unconjugated hydrophilic BAs plasma levels and enhanced hepatic expression of
BA synthesis and transport genes. A. muciniphila correlated with circulating BAs and liver lipid and
BA metabolism genes, suggesting a role of this bacterium in BA signaling. Beneficial effects of A.
muciniphila and quercetin combination are driven by gut microbiota modulation, the shift in BAs and
the gut-liver bile flow enhancement.
Materia
Palabras clave
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SI
ID proyecto
- info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20/00690/ES/FACTORES DE SUSCEPTIBILIDAD Y BIOMARCADORES NO INVASIVOS PARA LA ESTEATOSIS HEPATICA INDUCIDA POR VALPROATO EN PACIENTES PEDIATRICOS CON EPILEPSIA //
- info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17/01089/ES/NUEVOS MECANISMOS Y BIOMARCADORES DIAGNOSTICOS EN LA COLESTASIS IATROGENICA//
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/PID2020-120363RB-I00/ES/MICROBIOTA INTESTINAL Y DAÑO HEPATICO POR FARMACOS (DILI). TRANSFERENCIA DE PERFILES ESPECIFICOS Y MODULACION DE MICROBIOTA EN MODELOS EXPERIMENTALES DE DILI POR CLAVULANATO//
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/BFU2017-87960-R/ES/EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD//
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