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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Juárez‐Fernández, María | |
dc.contributor.author | Porras, David | |
dc.contributor.author | Petrov, Petar | |
dc.contributor.author | Román-Sagüillo, Sara | |
dc.contributor.author | García Mediavilla, María Victoria | |
dc.contributor.author | Soluyanova, Polina | |
dc.contributor.author | Martínez Flórez, Susana | |
dc.contributor.author | González Gallego, Javier | |
dc.contributor.author | Nistal González, Maria Esther | |
dc.contributor.author | Jover, Ramiro | |
dc.contributor.author | Sánchez Campos, Sonia | |
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dc.contributor.other | Medicina y Cirugia Animal | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-01-29T12:36:57Z | |
dc.date.available | 2024-01-29T12:36:57Z | |
dc.identifier.citation | Juárez-Fernández, M., Porras, D., Petrov, P., Román-Sagüillo, S., García-Mediavilla, M. V., Soluyanova, P., Martínez-Flórez, S., González-Gallego, J., Nistal González, E., Jover, R., & Sánchez-Campos, S. (2021). The synbiotic combination of akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants, 10(12). https://doi.org/10.3390/ANTIOX10122001 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17886 | |
dc.description.abstract | [EN] Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), so synbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention together with the administration of the bacteria Akkermansia muciniphila and the antioxidant quercetin in an in vivo model of early obesity and NAFLD. 21-day-old rats were fed with control or high-fat diet for six weeks. Then, all animals received control diet supplemented with/without quercetin and/or A. muciniphila for three weeks. Gut microbiota, NAFLD-related parameters, circulating bile acids (BAs) and liver gene expression were analyzed. The colonization with A. muciniphila was associated with less body fat, while synbiotic treatment caused a steatosis remission, linked to hepatic lipogenesis modulation. The synbiotic promoted higher abundance of Cyanobacteria and Oscillospira, and lower levels of Actinobacteria, Lactococcus, Lactobacillus and Roseburia. Moreover, it favored elevated unconjugated hydrophilic BAs plasma levels and enhanced hepatic expression of BA synthesis and transport genes. A. muciniphila correlated with circulating BAs and liver lipid and BA metabolism genes, suggesting a role of this bacterium in BA signaling. Beneficial effects of A. muciniphila and quercetin combination are driven by gut microbiota modulation, the shift in BAs and the gut-liver bile flow enhancement. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Basel: MDPI AG | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | Akkermansia muciniphila | es_ES |
dc.subject.other | Childhood obesity | es_ES |
dc.subject.other | Gut microbiota | es_ES |
dc.subject.other | Quercetin | es_ES |
dc.subject.other | Synbiotic | es_ES |
dc.title | The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/antiox10122001 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20/00690/ES/FACTORES DE SUSCEPTIBILIDAD Y BIOMARCADORES NO INVASIVOS PARA LA ESTEATOSIS HEPATICA INDUCIDA POR VALPROATO EN PACIENTES PEDIATRICOS CON EPILEPSIA // | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17/01089/ES/NUEVOS MECANISMOS Y BIOMARCADORES DIAGNOSTICOS EN LA COLESTASIS IATROGENICA// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/PID2020-120363RB-I00/ES/MICROBIOTA INTESTINAL Y DAÑO HEPATICO POR FARMACOS (DILI). TRANSFERENCIA DE PERFILES ESPECIFICOS Y MODULACION DE MICROBIOTA EN MODELOS EXPERIMENTALES DE DILI POR CLAVULANATO// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/BFU2017-87960-R/ES/EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2076-3921 | |
dc.journal.title | Antioxidants | es_ES |
dc.volume.number | 10 | es_ES |
dc.issue.number | 12 | es_ES |
dc.page.initial | 2001 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109.09 Fisiología | es_ES |
dc.subject.unesco | 2411 Fisiología Humana | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2076-3921/10/12/2001 | * |
dc.description.project | This work was supported by grants from Ministerio de Economía y Competitividad/FEDER (BFU2017-87960-R; PID2020-120363RB-I0), Junta de Castilla y León (FEDER) (GRS2126/A/2020; LE063U16; LE017P20), and Instituto de Salud Carlos III (PI17/01089, PI20/00690, cofunded by European Regional Development Fund “A way to achieve Europe”). MJF was supported by a fellowship from Ministerio de Ciencia, Innovación y Universidades (FPU18/06257); DP and SRS by a fellow-ship from Junta de Castilla y León cofunded by the European Social Fund; PP by Sara Borrell Postdoctoral Contract CD18/00158 from the Instituto de Salud Carlos III, cofunded by the European Social Fundation. CIBERehd is funded by the Instituto de Salud Carlos III, Spain. | es_ES |
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