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dc.contributor | Facultad de Ciencias Biologicas y Ambientales | es_ES |
dc.contributor.author | Lombó Alonso, Marta | |
dc.contributor.author | Herráez Ortega, María Paz | |
dc.contributor.other | Biologia Celular | es_ES |
dc.date | 2021 | |
dc.date.accessioned | 2024-02-06T11:42:13Z | |
dc.date.available | 2024-02-06T11:42:13Z | |
dc.identifier.citation | Lombó, M., & Herráez, M. P. (2021). Paternal inheritance of bisphenol a cardiotoxic effects: The implications of sperm epigenome. International Journal of Molecular Sciences, 22(4), Article e2125. https://doi.org/10.3390/IJMS22042125 | es_ES |
dc.identifier.other | https://www.mdpi.com/1422-0067/22/4/2125 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18095 | |
dc.description.abstract | [EN] Parental exposure to bisphenol A (BPA) has been linked to a greater incidence of congenital diseases. We have demonstrated that BPA induces in zebrafish males an increase in the acetylation of sperm histones that is transmitted to the blastomeres of the unexposed progeny. This work is aimed to determine whether histone hyperacetylation promoted by paternal exposure to BPA is the molecular mechanism underlying the cardiogenesis impairment in the descendants. Zebrafish males were exposed to 100 and 2000 µg/L BPA during early spermatogenesis and mated with non-exposed females. We analyzed in the progeny the expression of genes involved in cardiogenesis and the epigenetic profile. Once the histone hyperacetylation was confirmed, treatment with epigallocatechin gallate (EGCG), an inhibitor of histone acetyltransferases, was assayed on F1 embryos. Embryos from males exposed to 2000 µg/L BPA overexpressed the transcription factor hand2 and the receptor esr2b, showing their own promoters—as well as that of kat6a—an enrichment in H3K9ac. In embryos treated with EGCG, both gene expression and histone acetylation (global and specific) returned to basal levels, and the phenotype was recovered. As shown by the results, the histone hyperacetylated landscape promoted by BPA in the sperm alters the chromatin structure of the progeny, leading to the overexpression of the histone acetyltransferase and genes involved in cardiogenesis | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Biología | es_ES |
dc.subject.other | Cardiogenesis | es_ES |
dc.subject.other | Zebrafish | es_ES |
dc.subject.other | Paternal transmission | es_ES |
dc.subject.other | Epigenetics | es_ES |
dc.subject.other | Bisphenol A | es_ES |
dc.subject.other | Paternal exposure | es_ES |
dc.subject.other | Histone acetylation | es_ES |
dc.subject.other | Sperm epigenome | es_ES |
dc.subject.other | Heart development | es_ES |
dc.title | Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/ijms22042125 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/AGL2014-53167-C3-3-R/ES/Efecto de contaminantes emergentes en células de la línea germinal masculina: contribución paterna al desarrollo y herencia transgeneracional | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de Promoción del Talento y su Empleabilidad/BES- 2015-071885/ES | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1422-0067 | |
dc.journal.title | International Journal of Molecular Sciences | es_ES |
dc.volume.number | 22 | es_ES |
dc.issue.number | 4 | es_ES |
dc.page.initial | 2125 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2401.07 Embriología Animal | es_ES |
dc.subject.unesco | 2407 Biología Celular | es_ES |
dc.subject.unesco | 3214 Toxicología | es_ES |
dc.subject.unesco | 2409.99 Otros (Epigenética) | es_ES |
dc.description.project | This work was funded by the Spanish Ministry of Economy and Competitiveness (Project AGL2014-53167-C3-3-R; PhD Grant BES- 2015-071885) and it was awarded by Fundación Carolina Rodríguez (Universidad de León) in the 24th edition of “Premios Mariano Rodríguez para jóvenes investigadores” | es_ES |
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