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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Pérez de Prado, Armando | |
dc.contributor.author | Pérez Martínez, Claudia | |
dc.contributor.author | Regueiro Purriños, Marta María | |
dc.contributor.author | Cuellas Ramón, Carlos | |
dc.contributor.author | López Benito, María | |
dc.contributor.author | Gonzalo Orden, José Manuel | |
dc.contributor.author | Estévez Loureiro, Rodrigo | |
dc.contributor.author | Cortina Rivero, Ana Isabel | |
dc.contributor.author | Viñuela Baragaño, David | |
dc.contributor.author | Rodríguez-Áltonaga Martínez, José Antonio | |
dc.contributor.author | Tellez, Armando | |
dc.contributor.author | Fernández Vázquez, Felipe | |
dc.contributor.other | Medicina y Cirugia Animal | es_ES |
dc.date | 2020 | |
dc.date.accessioned | 2024-02-29T12:13:43Z | |
dc.date.available | 2024-02-29T12:13:43Z | |
dc.identifier.citation | de Prado, A. P., Pérez-Martínez, C., Regueiro-Purriños, M., Cuellas-Ramón, C., López-Benito, M., Gonzalo-Orden, J. M., Estévez-Loureiro, R., Cortina-Rivero, A. I., Viñuela-Baragaño, D., Altonaga, J. R., Tellez, A., & Fernández-Vázquez, F. (2020). Development and evaluation of a disease large animal model for preclinical assessment of renal denervation therapies. Animals, 10(9), 1-15. https://doi.org/10.3390/ANI10091446 | es_ES |
dc.identifier.other | https://www.mdpi.com/2076-2615/10/9/1446 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/18540 | |
dc.description.abstract | [EN] New-generation catheters-based renal denervation (RDN) is under investigation for the treatment of uncontrolled hypertension (HTN). We assessed the feasibility of a large animal model of HTN to accommodate the human RDN devices. Ten minipigs were instrumented to measure blood pressure (BP) in an awake-state. HTN was induced with subcutaneous 11-deoxycorticosterone (DOCA, 100 mg/kg) implants. Five months after, the surviving animals underwent RDN with the Symplicity® system. Norepinephrine (NE) renal gradients were determined before and 1 month after RDN. Renal arteries were processed for histological (hematoxylin-eosin, Movat pentachrome) and immunohistochemical (S100, tyrosine-hydroxylase) analyses. BP significantly rose after DOCA implants. Six animals died prematurely, mainly from infectious causes. The surviving animals showed stable BP levels after 5 months. One month after RDN, nerve damage was showed in three animals, with impedance drop >10%, NE gradient drop and reduction in BP. The fourth animal showed no nerve damage, impedance drop <10%, NE gradient increase and no change in BP. In conclusion, the minipig model of DOCA-induced HTN is feasible, showing durable effects. High mortality should be addressed in next iterations of this model. RDN may partially offset the DOCA-induced HTN. Impedance drop and NE renal gradient could be markers of RDN success. | es_ES |
dc.language | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Veterinaria | es_ES |
dc.subject.other | Hypertension | es_ES |
dc.subject.other | DOCA | es_ES |
dc.subject.other | Renal denervation | es_ES |
dc.subject.other | Radiofrequency | es_ES |
dc.subject.other | Swine | es_ES |
dc.subject.other | Histology | es_ES |
dc.subject.other | Immunohistochemistry | es_ES |
dc.title | Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3390/ANI10091446 | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 2076-2615 | |
dc.journal.title | Animals | es_ES |
dc.volume.number | 10 | es_ES |
dc.issue.number | 9 | es_ES |
dc.page.initial | 1446 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109 Ciencias Veterinarias | es_ES |
dc.description.project | This research was funded by Consejería de Salud, Junta de Castilla and Leon, Spain, the Grant GRS 1001/A/2014. | es_ES |
dc.description.project | We want to thank Medtronic Iberia for the donation of the Symplicity catheters used in this experiment. | es_ES |
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