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Título
Plasma peptidases as prognostic biomarkers in patients with first-episode psychosis
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Psychiatry Research
Número de la revista
2
Cita Bibliográfica
Seco Calvo, J. Á.; Fernández Atucha, A.; Echevarría, E.; Larrinaga, G.; Idoate Gil, J.; Martínez Cengotitabengoa, M.; González Pinto, A. M.; Irazusta Astiarazan, J. (2015). Plasma peptidases as prognostic biomarkers in patients with first-episode psychosis. Psychiatry Research, 228, 197-202(2), https://doi.org/10.1016/J.PSYCHRES.2015.04.027
Editorial
Elsevier
Fecha
2015
ISSN
0165-1781
Resumen
[EN] The plasma activity of nine aminopeptidases was monitored over a year in first-episode psychotic patients. We observed significant differences in aminopeptidase B (APB), aminopeptidase N (APN) and dipeptidyl peptidase IV (DPPIV), but not in puromycin-sensitive aminopeptidase (PSA), prolyl endopeptidase (PEP), cysteine aminopeptidase (Cys-AP), aspartate aminopeptidase (Asp-AP), glutamate aminopeptidase (Glu) or piroglutamate aminopeptidase (PGI) in these patients compared to controls, and also a progressive increase in plasma activity, correlated to changes in scores on clinical scales, Global Assessment of Functioning scale (GAF) and Hamilton Depression Rating Scale (HDRS), at 1 month of follow-up. At 1 month after diagnosis, the median score obtained by patients on the GAF was negatively associated with the plasma activity of APB and PEP measured at the beginning of the psychotic episode, indicating a role as a negative prognostic factor that can predict psychiatric symptomatology. In the case of HDRS, scores at 1 month after diagnosis were found to be positively associated with the initial plasma activity of DPPIV, APN and PSA, indicating that their initial elevation is a negative prognostic factor that can predict subsequent depressive symptomatology. Taken together, these results suggest a pathophysiological involvement of plasma peptidases and indicate that aminopeptidase activity can predict the course of first-episode psychosis patients, acting as a prognostic indicator.
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