Compartir
Título
PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Transplant International
Cita Bibliográfica
del Río, M. L., Buhler, L., Gibbons, C., Tian, J., & Rodríguez Barbosa, J. I. (2008). PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transplant international : official journal of the European Society for Organ Transplantation, 21(11), 1015–1028. https://doi.org/10.1111/j.1432-2277.2008.00726.x
Editorial
Frontiers Media
Fecha
2008
ISSN
0934-0874
Resumen
[EN] Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins
Materia
Palabras clave
Peer review
SI
URI
DOI
Aparece en las colecciones
- Artículos [5086]
Ficheros en el ítem
Nombre:
Tamaño:
1.176
xmlui.dri2xhtml.METS-1.0.size-megabytes
Formato:
Adobe PDF