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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Río González, María Luisa del | |
dc.contributor.author | Buhler, Leo | |
dc.contributor.author | Gibbons, Carrie | |
dc.contributor.author | Tian, Jiong | |
dc.contributor.author | Rodríguez Barbosa, José Ignacio | |
dc.contributor.other | Inmunologia | es_ES |
dc.date | 2008 | |
dc.date.accessioned | 2024-05-03T07:31:00Z | |
dc.date.available | 2024-05-03T07:31:00Z | |
dc.identifier.citation | del Río, M. L., Buhler, L., Gibbons, C., Tian, J., & Rodríguez Barbosa, J. I. (2008). PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. Transplant international : official journal of the European Society for Organ Transplantation, 21(11), 1015–1028. https://doi.org/10.1111/j.1432-2277.2008.00726.x | es_ES |
dc.identifier.issn | 0934-0874 | |
dc.identifier.uri | https://hdl.handle.net/10612/20293 | |
dc.description.abstract | [EN] Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins | es_ES |
dc.language | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Inmunología | es_ES |
dc.subject | Sanidad animal | es_ES |
dc.subject.other | Antigen-presenting cells | es_ES |
dc.subject.other | BTLA | es_ES |
dc.subject.other | CD160 | es_ES |
dc.subject.other | Co-inhibition | es_ES |
dc.subject.other | Co-stimulation | es_ES |
dc.subject.other | HVEM | es_ES |
dc.subject.other | PD-1 | es_ES |
dc.subject.other | PD-L1 | es_ES |
dc.subject.other | PD-L2 | es_ES |
dc.subject.other | Peripheral tolerance | es_ES |
dc.subject.other | T cells | es_ES |
dc.subject.other | Transplantation | es_ES |
dc.title | PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | doi:10.1111/j.1432-2277.2008.00726.x | |
dc.description.peerreviewed | SI | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1432-2277 | |
dc.journal.title | Transplant International | es_ES |
dc.volume.number | 21 | es_ES |
dc.page.initial | 1015 | es_ES |
dc.page.final | 1028 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3109.03 Inmunología | es_ES |
dc.description.project | This work has been supported by grants FIS 01-3026 and FIS PI-050021 of Fondo de Investigaciones Sanitarias (Ministerio de Sanidad y Consumo, Spanish Government, Spain) to JIRB | es_ES |
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