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Título
LIGHT/HVEM/LTβR Interaction as a Target for the Modulation of the Allogeneic Immune Response in Transplantation
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
American Journal of Transplantation
Número de la revista
3
Cita Bibliográfica
Del Rio, Schneider, Fernández Renedo, Pérez Simón, & Rodríguez Barbosa. (2013). LIGHT/HVEM/LTβR interaction as a target for the modulation of the allogeneic immune response in transplantation [Review of LIGHT/HVEM/LTβR interaction as a target for the modulation of the allogeneic immune response in transplantation]. American Journal of Transplantation, 13(3), 541-551. https://doi.org/10.1111/AJT.12089
Editorial
Elsevier
Fecha
2013
ISSN
1600-6135
Resumen
[EN] The exchange of information during interactions of T cells with dendritic cells, B cells or other T cells regulates the course of T, B and DC-cell activation and their differentiation into effector cells. The tumor necrosis factor superfamily member LIGHT (homologous to lymphotoxin, exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T lymphocytes) is transiently expressed upon T cell activation and modulates CD8 T cell-mediated alloreactive responses upon herpes virus entry mediator (HVEM) and lymphotoxin β receptor (LTβR) engagement. LIGHT-deficient mice, or WT mice treated with LIGHT-targeting decoy receptors HVEM-Ig, LTβR-Ig or sDcR3-Ig, exhibit prolonged graft survival compared to untreated controls, suggesting that LIGHT modulates the course and severity of graft rejection. Therefore, targeting the interaction of LIGHT with HVEM and/or LTβR using recombinant soluble decoy receptors or monoclonal antibodies represent an innovative therapeutic strategy for the prevention and treatment of allograft rejection and for the promotion of donor-specific tolerance. This review discusses how targeting the interaction of LIGHT with HVEM and/or LTbR using recombinant soluble decoy receptors or monoclonal antibodies may represent an innovative therapeutic intervention for the prevention and treatment of allograft rejection and promotion of donor-specific tolerance. © 2013 The American Society of Transplantation and the American Society of Transplant Surgeons
Materia
Palabras clave
Peer review
SI
ID proyecto
- info:eu-repo/grantAgreement/Junta de Castilla y León/ / LE007A10-2/ES/ El papel de la ruta de co-estimulación HVEM/LIGHT como diana terapéutica para la prevención del rechazo//
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