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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Pereda, Pablo | |
dc.contributor.author | García, Juan J. | |
dc.contributor.author | Sierra Vega, Matilde | |
dc.contributor.author | Fernández, Nélida | |
dc.contributor.author | Sahagún , Ana M. | |
dc.contributor.author | Diez Liébana, María José | |
dc.contributor.other | Farmacologia | es_ES |
dc.date | 2002-03-01 | |
dc.date.accessioned | 2015-07-29T12:22:11Z | |
dc.date.available | 2015-07-29T12:22:11Z | |
dc.date.issued | 2015-07-29 | |
dc.identifier.citation | Pharmacological research, 2002, vol. 45, n. 4 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10612/4442 | |
dc.description | P. 285-289 | es_ES |
dc.description.abstract | The pharmacokinetics of levamisole after intra-arterial administration of 12.5, 16 and 20 mg kg−1 was investigated in rabbits. After compartmental analysis, the disposition of levamisole was well described by a two-compartment open model with mean values ± SD of: = 0.1650 ± 0.0839, 0.1611 ± 0.0298, 0.2312 ± 0.0540 min−1, and = 0.0118 ± 0.0022, 0.0125 ± 0.0026, 0.0120 ± 0.0024 min−1, for the three doses studied, respectively. There were no doserelated differences (one-way analyses of variance (ANOVA), P 0.05) in , , total body clearance (Cl) and volume of distribution at steady state (Vss). The AUC increased significantly with the doses (249.7, 376.7 and 562.5 μg min ml−1). After non-compartmental analysis there were no significant differences in plasma elimination rate constant ( ), MRT and Vss as a function of dose, but these differences were significant for Cl, between 16 and 20 mg kg−1, and AUC (one-way ANOVA, P 0.05). The two-way ANOVA showed no significant differences between the values obtained for the three doses when – , Cl, Vss and Va were compared while AUC showed significant changes. On the other hand, the pharmacokinetic analysis (compartmental and non-compartmental) showed significant differences in AUC, Cl, Vss and Va, but there were no significant differences when – were compared. The slow clearance of levamisole by rabbit lung compared to a high pulmonary blood flow rate makes the possibility of significant first-pass lung metabolism unlikely in this animal species. | es_ES |
dc.language | eng | es_ES |
dc.subject | Zoología | es_ES |
dc.subject.other | Levamisol | es_ES |
dc.subject.other | Pulmonary first-pass | es_ES |
dc.subject.other | Rabbits | es_ES |
dc.title | Intra-arterial pharmacokinetics and pulmonary first-pass of levamisole in rabbits | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.description.peerreviewed | SI | es_ES |
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