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Título
Therapeutic effects of psyllium in type 2 diabetic patients
Autor
Facultad/Centro
Área de conocimiento
Cita Bibliográfica
European journal of clinical nutrition, 2002, n. 56
Editorial
Nature publishing group
Fecha
2002-06-24
Resumen
The study included three phases: phase 1 (1 week), phase 2 (treatment, 14 g fibre=day, 6 weeks) and phase 3 (4 weeks).
At the end of each phase a clinical evaluation was performed after the ingestion of a test breakfast of 1824.2 kJ (436 kcal).
Measurements included concentrations of blood glucose, insulin, fructosamine, GHbA1c, C-peptide and 24 h urinary glucose
excretion. In addition, uric acid, cholesterol and several mineral and vitamin concentrations were also evaluated.
Twenty type 2 diabetic patients (12 men and 8 women) participated in the study with a mean age of 67.4 y for men
and 66 y for women. The mean body mass index of men was 28.2 kg=m2 and that of women 25.9 kg=m2.
Glucose absorption decreased significantly in the presence of psyllium (12.2%); this reduction is not associated with an
important change in insulin levels (5%). GHbA1c, C-peptide and 24 h urinary glucose excretion decreased (3.8, 14.9 and 22.5%,
respectively) during the treatment with fibre (no significant differences) as well as fructosamine (10.9%, significant differences).
Psyllium also reduced total and LDL cholesterol (7.7 and 9.2%, respectively, significant differences), and uric acid (10%,
significant difference). Minerals and vitamins did not show important changes, except sodium that increased significantly after
psyllium administration.
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