Compartir
Título
Influence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbits
Autor
Facultad/Centro
Área de conocimiento
Datos de la obra
The Journal of pharmacology and experimental therapeutics, 1998, vol. 286, n. 2
Editor
ASPET
Fecha
1998-04-08
Zusammenfassung
Fiber formulations are used in human nutrition owing to their
beneficial properties for health. It is probable that ingestion of
fiber coincides with the oral administration of drugs, and a
modification of its oral absorption, and therefore of its pharmacokinetics,
can appear. In the present study, the compartmental
and noncompartmental pharmacokinetic parameters of ethinylestradiol
(EE) in rabbits after oral administration were
determined. It was also studied whether the presence of two
different fiber formulations [A, wheat bran (76.5%), fruit fiber
(12%) and guar gum (2%) and B, Plantago ovata seeds (65%)
and P. ovata seed cuticles (2.2%)] in the gastrointestinal tract
modified the pharmacokinetics of EE when administered at the
same time. Three groups of rabbits were used: control, fiber A
and fiber B. The animals in all three groups received 1 mg/kg b.
wt. EE. The estrogen was administered alone in the control
group and in the presence of 4 g of fiber A and fiber B,
respectively, in the other two groups. After compartmental
(two-compartment open model) and noncompartmental analyses
of plasma concentrations, statistical analysis revealed that
the presence of fiber (both A and B) decreased between 29%
and 35% the extent of EE absorbed (represented by the pharmacokinetic
parameters area under the curve and the maximum
plasma concentration) without affecting the rate of the
absorption process (represented by the time to reach maximum
concentration and the absorption rate constant).
Materia
Palabras clave
Peer review
SI
URI
Aparece en las colecciones
- Untitled [4523]
Dateien zu dieser Ressource
Tamaño:
82.88
xmlui.dri2xhtml.METS-1.0.size-kilobytes
Formato:
Adobe PDF