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Título
Study on Viability and Chondrogenic Differentiation of Cryopreserved Adipose Tissue-Derived Mesenchymal stromal Cells for future use in regenerative medicine
Autor
Facultad/Centro
Área de conocimiento
Datos de la obra
Cryobiology (2015), n. 71
Editor
Elsevier
Fecha
2015-07-23
Abstract
Adipose-derived mesenchymal stromal cells are promising as a regenerative therapy tool for defective
tissues in mesenchymal lineage, including fat, bone, cartilage, and blood vessels. In potential future clinical
applications, adipose-derived stem cell cryopreservation is an essential fundamental technology. The
aim of this study is to define an adequate protocol for the cryopreservation of adipose-derived mesenchymal
stromal cells, by comparing various protocols so as to determine the effects of cryopreservation on
viability and chondrogenic differentiation potential of adipose-derived stem cells upon freeze-thawing of
AT-MSCs colonies cryopreserved with standard and modified protocols, using flow cytometry and confocal
microscopy. The study concludes that adipose-derived mesenchymal stromal cells could be long-term
cryopreserved without any loss of their proliferative or differentiation potential
Materia
Palabras clave
Peer review
SI
URI
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