RT info:eu-repo/semantics/article
T1 Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence
A1 San Miguel de Vega, Beatriz
A1 Fernández Palanca, Paula
A1 Mauriz Gutiérrez, José Luis
A1 Tuñón González, María Jesús
A1 González Gallego, Javier
A2 Fisiologia
K1 Fisiología
K1 Antioxidant
K1 Cirrhosis
K1 Hepatic fibrosis
K1 Liver fibrosis
K1 Melatonin
AB [EN] Hepatic fibrosis is a reversible response to either acute or chronic cellular injury froma wide variety of etiologies, characterized by excessive deposition of extracellularmatrix  resulting  in  liver  dysfunction  and  cirrhosis.  Melatonin  (N‐acetyl‐5‐methoxytryptamine), the main product secreted by the pineal gland, is a multitaskingindolamine with important physiological functions such as anti‐inflammatory andantioxidant actions, modulation of circadian rhythms, and immune system enhance-ment. Among the numerous biological activities of melatonin, its antifibrotic effectshave received increasingly more attention. In this study, we performed a systematicreview of publications of the last 10 years evaluating the mechanisms of action ofmelatonin against liver fibrosis. The study protocol was registered at PROSPERO(CRD42022304744). Literature research was performed employing PubMed,Scopus, and Web of Science (WOS) databases, and after screening, 29 articleswere included. Results from the selected studies provided denoted the usefulactions of melatonin on the development, progression, and evolution of liver fibrosis.Melatonin antifibrotic effects in the liver involved the reduction of profibrogenicmarkers and modulation of several cellular processes and molecular pathways,mainly acting as an antioxidant and anti‐inflammatory agent. In addition, theindolamine influenced different molecular processes, such as hepatocyte apoptosis,modulation of autophagy and mitophagy, restoration of circadian rhythms, andmodulation of microRNAs, among others. Although some limitations have beenfound regarding variability in the study design, the findings here summarized displaythe potential role of melatonin in ameliorating the development of liver fibrosis andits possible progression to liver cirrhosis and hepatocarcinoma
PB Wiley-Blackwell
SN 0021-9541
LK http://hdl.handle.net/10612/15383
UL http://hdl.handle.net/10612/15383
NO San-Miguel, B., Fernández-Palanca, P., Mauriz, J. L., Tuñón, M. J., & González-Gallego, J. (2022). Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence [Review of Beneficial effects of melatonin on liver fibrosis: A systematic review of current biological evidence]. Journal of Cellular Physiology, 237(7), 2740-2757. John Wiley and Sons Inc. https://doi.org/10.1002/JCP.30735
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 02-may-2024