RT info:eu-repo/semantics/article
T1 Assessment of the antioxidant/hypolipidemic relationship of sideritis hyssopifolia in an experimental animal model
A1 Coto Alcaraz, Esther
A1 Fernández Martínez, María Nélida
A1 Diez Liébana, María José
A1 Sahagún Prieto, Ana María
A1 Sierra Vega, Matilde
A1 García Viéitez, Juan José
A2 Farmacologia
K1 Farmacología
K1 Antioxidant activity
K1 Atherogenic index
K1 Cholesterol
K1 Rabbit
K1 Sideritis hyssopifolia
K1 3109 Ciencias Veterinarias
K1 3109.08 Farmacología
AB [EN] Many publications have described the potential cardioprotective action of different medicinal plants, relating this effect with blood lipid levels. However, these publications do not justify the right amount of plant administered, which can vary greatly. Sideritis hyssopifolia is a little woody plant endemic to western and southwestern Europe. We have quantified its antioxidant activity, which can be used as an indicator of its cardioprotective action. This study evaluates the antioxidant capacity of Sideritis hyssopifolia to design a feed whose hypolipidemic effects are proven in cholesterol-fed New Zealand rabbits. Antioxidant action was assessed in infusions, which were prepared with 1 or 3 g of plant in 200 mL of water by using an ABTS assay and expressed as Ascorbic acid Equivalent Antioxidant Capacity (AEAC). Aqueous infusions with infusion times of 10 min and prepared with 3 g plant exhibited the strongest antioxidant activity. Sideritis hyssopifolia showed an intermediate antioxidant capacity for the concentrations and times of the infusion tested. According to our results, we suggest incorporating 2.36 g of S. hyssopifolia every 150 g of rabbit feeding stuff (15.73 g/kg). This chow decreased cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides levels in cholesterol-fed rabbits, as well as the atherogenic index. This reduction was similar to that obtained with simvastatin.
PB MDPI
LK https://hdl.handle.net/10612/17694
UL https://hdl.handle.net/10612/17694
NO .Coto, E., Fernandez, N., Garcia, J. J., Diez, M. J., Sahagun, A. M., & Sierra, M. (2019). Assessment of the antioxidant/hypolipidemic relationship of sideritis hyssopifolia in an experimental animal model. Molecules, 24(11). https://doi.org/10.3390/MOLECULES24112049
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 21-may-2024