RT info:eu-repo/semantics/article
T1 The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation
A1 Juárez‐Fernández, María
A1 Porras, David
A1 Petrov, Petar
A1 Román-Sagüillo, Sara
A1 García Mediavilla, María Victoria
A1 Soluyanova, Polina
A1 Martínez Flórez, Susana
A1 González Gallego, Javier
A1 Nistal González, Maria Esther
A1 Jover, Ramiro
A1 Sánchez Campos, Sonia
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A2 Medicina y Cirugia Animal
K1 Fisiología
K1 Akkermansia muciniphila
K1 Childhood obesity
K1 Gut microbiota
K1 Quercetin
K1 Synbiotic
K1 3109.09 Fisiología
K1 2411 Fisiología Humana
AB [EN] Gut microbiota plays a key role in obesity and non-alcoholic fatty liver disease (NAFLD), sosynbiotics could be a therapeutic alternative. We aim to evaluate a nutritional intervention togetherwith the administration of the bacteria Akkermansia muciniphila and the antioxidant quercetin inan in vivo model of early obesity and NAFLD. 21-day-old rats were fed with control or high-fatdiet for six weeks. Then, all animals received control diet supplemented with/without quercetinand/or A. muciniphila for three weeks. Gut microbiota, NAFLD-related parameters, circulatingbile acids (BAs) and liver gene expression were analyzed. The colonization with A. muciniphilawas associated with less body fat, while synbiotic treatment caused a steatosis remission, linked tohepatic lipogenesis modulation. The synbiotic promoted higher abundance of Cyanobacteria andOscillospira, and lower levels of Actinobacteria, Lactococcus, Lactobacillus and Roseburia. Moreover, itfavored elevated unconjugated hydrophilic BAs plasma levels and enhanced hepatic expression ofBA synthesis and transport genes. A. muciniphila correlated with circulating BAs and liver lipid andBA metabolism genes, suggesting a role of this bacterium in BA signaling. Beneficial effects of A.muciniphila and quercetin combination are driven by gut microbiota modulation, the shift in BAs andthe gut-liver bile flow enhancement.
PB Basel: MDPI AG
LK https://hdl.handle.net/10612/17886
UL https://hdl.handle.net/10612/17886
NO Juárez-Fernández, M., Porras, D., Petrov, P., Román-Sagüillo, S., García-Mediavilla, M. V., Soluyanova, P., Martínez-Flórez, S., González-Gallego, J., Nistal González, E., Jover, R., & Sánchez-Campos, S. (2021). The synbiotic combination of akkermansia muciniphila and quercetin ameliorates early obesity and NAFLD through gut microbiota reshaping and bile acid metabolism modulation. Antioxidants, 10(12). https://doi.org/10.3390/ANTIOX10122001
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 20-may-2024