RT info:eu-repo/semantics/article
T1 Goats Naturally Infected with the Spanish Goat Encephalitis Virus (SGEV): Pathological Features and An Outbreak
A1 Balseiro Morales, Ana María
A1 Pérez Matínez, Claudia
A1 Dagleish, Mark. P.
A1 Royo, Luis J.
A1 Polledo, Laura
A1 García Marín, Juan Francisco
A2 Sanidad Animal
K1 Sanidad animal
K1 Spanish goat encephalitis virus (SGEV)
K1 Goat
K1 Outbreak
K1 Histopathology
K1 Immunohistochemistry
K1 3109 Ciencias Veterinarias
AB [EN] In autumn 2011, a disease outbreak caused by Spanish goat encephalitis virus (SGEV) was reported in a herd of goats from Asturias (north-western Spain), expanding the known geographic distribution of tick-borne encephalitis in Europe. The virus was classified as a new subtype (subspecies) within the Louping-ill virus species of the mammalian tick-borne flavivirus group. The aims of the present study were to describe the pathology in goats naturally infected with SGEV, as well as discuss the pathogenesis of the disease in that outbreak. A total of 22/85 (25.88%) goats (20 adults and 2 kids) died between October 2011 and June 2012, showing neurological clinical signs. Over three years, the mortality rate in the herd reached 100%. Neuropathological lesions caused by SGEV were severe and widespread throughout the central nervous system but were more severe and numerous in the proximal cervical spinal cord, medulla oblongata, pons and cerebellar cortex. They consisted of neuron necrosis, neuronophagia, mononuclear inflammatory cell perivascular cuffs (lymphocytes, plasma cells and macrophages) and gliosis. The distribution of viral antigens was restricted to the cytoplasm of neurons in several brain areas but not associated with inflammatory foci nor inflammatory cells. SGEV should be considered a significant pathogen of goats that results in severe neurological clinical disease and high mortality.
PB MDPI
LK https://hdl.handle.net/10612/18588
UL https://hdl.handle.net/10612/18588
NO Balseiro, A., Pérez-Martínez, C., Dagleish, M. P., Royo, L. J., Polledo, L., & García Marín, J. F. (2023). Goats Naturally Infected with the Spanish Goat Encephalitis Virus (SGEV): Pathological Features and An Outbreak. Animals, 13(1). https://doi.org/10.3390/ANI13010072
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 26-may-2024