RT info:eu-repo/semantics/article
T1 Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments
A1 Fernández Ugidos, Irene
A1 González Rodríguez, Paloma
A1 Santos Galdiano, María
A1 Font Belmonte, Enrique
A1 Anuncibay Soto, Berta
A1 Pérez Rodríguez, Diego
A1 Gonzalo Orden, José Manuel
A1 Fernández López, Arsenio
A2 Biologia Celular
K1 Biología
K1 Anti-inflammatories
K1 Astrocyte
K1 Axonal sprouting
K1 Cylinder test
K1 Doublecortin
K1 Focal brain ischemia
K1 Glial scar
K1 Inflammation
K1 Neuroprotection
K1 New neuron generation
K1 Transient stroke
K1 2407 Biología Celular
K1 3209.03 Evaluación de Medicamentos
K1 3205.07 Neurología
AB [EN] The inflammatory response plays an important role in neuroprotection and regeneration after ischemic insult. The use of non-steroidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects. In this context, the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stroke, but its ability to inhibit both cyclooxygenase isoforms (1 and 2) could be a promising strategy to modulate post-ischemic inflammation. This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats, measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area. We show that meloxicam's neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia. Moreover, meloxicam treatment modulated glial scar reactivity, which matched with an increase in axonal sprouting. However, this treatment decreased the formation of neuronal progenitor cells. This study discusses the dual role of anti-inflammatory treatments after stroke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies
PB Wolters Kluwer
SN 1673-5374
LK https://hdl.handle.net/10612/18706
UL https://hdl.handle.net/10612/18706
NO Ugidos, I.F., González-Rodríguez, P., Santos-Galdiano, M., Font-Belmonte, E., Anuncibay-Soto, B., Pérez-Rodríguez, D., Gonzalo-Orden, J., and Fernández-López, A. (2023). Neuroprotective effects of meloxicam on transient brain ischemia in rats: the two faces of anti-inflammatory treatments. Neural Regeneration Research, 18(9), 1961–1967. https://doi.org/10.4103/1673-5374.367846
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 20-may-2024