RT info:eu-repo/semantics/article
T1 Influence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbits
A1 Fernández, Nélida
A1 Diez Liébana, María José
A1 Terán Somaza, María Teresa
A1 García, Juan J.
A1 Calle Pardo, Ángela Pilar
A1 Sierra Vega, Matilde
A2 Farmacologia
K1 Ecología. Medio ambiente
K1 Farmacología
K1 Zoología
K1 Commercial fibers
K1 Pharmacokinetics
K1 Ethinylestradiol
K1 Rabbits
K1 Ratones
AB Fiber formulations are used in human nutrition owing to theirbeneficial properties for health. It is probable that ingestion offiber coincides with the oral administration of drugs, and amodification of its oral absorption, and therefore of its pharmacokinetics,can appear. In the present study, the compartmentaland noncompartmental pharmacokinetic parameters of ethinylestradiol(EE) in rabbits after oral administration weredetermined. It was also studied whether the presence of twodifferent fiber formulations [A, wheat bran (76.5%), fruit fiber(12%) and guar gum (2%) and B, Plantago ovata seeds (65%)and P. ovata seed cuticles (2.2%)] in the gastrointestinal tractmodified the pharmacokinetics of EE when administered at thesame time. Three groups of rabbits were used: control, fiber Aand fiber B. The animals in all three groups received 1 mg/kg b.wt. EE. The estrogen was administered alone in the controlgroup and in the presence of 4 g of fiber A and fiber B,respectively, in the other two groups. After compartmental(two-compartment open model) and noncompartmental analysesof plasma concentrations, statistical analysis revealed thatthe presence of fiber (both A and B) decreased between 29%and 35% the extent of EE absorbed (represented by the pharmacokineticparameters area under the curve and the maximumplasma concentration) without affecting the rate of theabsorption process (represented by the time to reach maximumconcentration and the absorption rate constant).
PB ASPET
YR 2015
FD 2015-07-29
LK http://hdl.handle.net/10612/4449
UL http://hdl.handle.net/10612/4449
NO The Journal of pharmacology and experimental therapeutics, 1998, vol. 286, n. 2
NO P. 870-874
DS BULERIA. Repositorio Institucional de la Universidad de León
RD 30-abr-2024