RT info:eu-repo/semantics/article T1 Antibody response of rainbow trout with single or double infections involving viral haemorrhagic septicaemia virus and infectious haematopoietic necrosis virus A1 Fregeneda Grandes, Juan Miguel A1 Skall, Helle Frank A1 Olesen, Niels Jørgen A2 Sanidad Animal K1 Inmunología K1 Sanidad animal K1 Veterinaria K1 Zoología K1 Trucha arcoiris K1 Inmunoglobulinas K1 Serología AB Juvenile rainbow trout Oncorhynchus mykiss were experimentally infected by immersionwith viral haemorrhagic septicaemia virus (VHSV), infectious haematopoietic necrosis virus(IHNV) or with both viruses. The presence of neutralizing antibodies in the sera of infected fish wereanalysed by 50% plaque neutralization tests (50%PNT). In Group 1 (infected with VHSV) and Group2 (infected with IHNV) neutralizing antibodies were found in 41% and 21% of the serum samples,respectively. No cross-reacting antibodies were found in these 2 groups. In Group 3 (infected withboth viruses) 30% of the samples showed neutralizing antibodies against VHSV, 21% against IHNVand 12% against both viruses. Fish in Group 3 developed a double specific antibody reaction whosekinetics and intensity (mean of log10 titres) were similar to the antibody response of the singleinfected groups. PB Inter-Research YR 2018 FD 2018-12-27 LK http://hdl.handle.net/10612/9270 UL http://hdl.handle.net/10612/9270 NO Diseases of aquatic organisms, 2009, vol. 83, n. 1 NO P. 23-29 DS BULERIA. Repositorio Institucional de la Universidad de León RD 30-abr-2024