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Título
Beneficial effect of physical exercise on telomere length and aging, and genetics of aging-associated noncommunicable diseases
Autor
Facultad/Centro
Área de conocimiento
Asignaturas
Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions
Datos de la obra
Estébanez, B., Rodriguez-Miguelez, P., Fernandez-Gonzalo, R., González-Gallego, J., & Cuevas, M. J. (2019). Beneficial effect of physical exercise on telomere length and aging, and genetics of aging-associated noncommunicable diseases. En Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions (pp. 509-538). Elsevier. https://doi.org/10.1016/B978-0-12-816193-7.00022-1
Editor
Academic Press (ELSEVIER)
Fecha
2019-08-25
Abstract
[EN] As organisms advance in age, telomere shortening occurs. Among the different causes involved in this process, lifestyle factors and certain alterations at cellular level, both related to cellular senescence process and organism aging, have been identified as responsible for this decrease in telomere length (TL). Cellular alterations that have been shown to play a predominant role in telomere shortening are telomerase activity, oxidative stress and inflammation. Telomere shortening, whether caused by or resulting from cellular senescence, has been related to the presence of age-related diseases, such as dementia, diabetes mellitus, chronic cardiovascular and pulmonary disease or skin disorders. The level of physical activity is one of life factors closely related to TL. Thus, regular physical activity promotes telomerase activity, decreases oxidative stress and inflammation, and increases the number of satellite cells, exerting, ultimately, a protective effect on telomeres.
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