dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | De Souza Fonseca, Pablo Augusto | |
dc.contributor.author | Alonso García, María | |
dc.contributor.author | Pelayo, Rocío | |
dc.contributor.author | Marina García, Héctor | |
dc.contributor.author | Esteban Blanco, Cristina | |
dc.contributor.author | Mateo Oyagüe, Javier | |
dc.contributor.author | Gutiérrez Gil, Beatriz | |
dc.contributor.author | Arranz Santos, Juan José | |
dc.contributor.author | Suárez Vega, Aroa | |
dc.contributor.other | Producción Animal | es_ES |
dc.date | 2022 | |
dc.date.accessioned | 2024-05-06T11:15:09Z | |
dc.date.available | 2024-05-06T11:15:09Z | |
dc.identifier.citation | Fonseca, P. A. S., Alonso García, M., Pelayo, R., Marina, H., Esteban Blanco, C., Mateo, J., Gutiérrez Gil, B., Arranz, J.-J., & Suárez-Vega, A. (2022). Integrated analyses of the methylome and transcriptome to unravel sex differences in the perirenal fat from suckling lambs. Frontiers in Genetics, 13. https://doi.org/10.3389/FGENE.2022.1035063 | es_ES |
dc.identifier.other | https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1035063/full | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/20399 | |
dc.description.abstract | [EN] In sheep, differences were observed regarding fat accumulation and fatty acid (FA) composition between males and females, which may impact the quality and organoleptic characteristics of the meat. The integration of different omics technologies is a relevant approach for investigating biological and genetic mechanisms associated with complex traits. Here, the perirenal tissue of six male and six female Assaf suckling lambs was evaluated using RNA sequencing and whole-genome bisulfite sequencing (WGBS). A multiomic discriminant analysis using multiblock (s)PLS-DA allowed the identification of 314 genes and 627 differentially methylated regions (within these genes), which perfectly discriminate between males and females. These candidate genes overlapped with previously reported QTLs for carcass fat volume and percentage of different FAs in milk and meat from sheep. Additionally, differentially coexpressed (DcoExp) modules of genes between males (nine) and females (three) were identified that harbour 22 of these selected genes. Interestingly, these DcoExp were significantly correlated with fat percentage in different deposits (renal, pelvic, subcutaneous and intramuscular) and were associated with relevant biological processes for adipogenesis, adipocyte differentiation, fat volume and FA composition. Consequently, these genes may potentially impact adiposity and meat quality traits in a sex-specific manner, such as juiciness, tenderness and flavour | es_ES |
dc.language | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Producción animal | es_ES |
dc.subject.other | RNA sequencing | es_ES |
dc.subject.other | Whole-genome bisulfite sequencing | es_ES |
dc.subject.other | Suckling lambs | es_ES |
dc.subject.other | Omics integration | es_ES |
dc.subject.other | Fat deposits | es_ES |
dc.subject.other | Perirenal fat | es_ES |
dc.title | Integrated analyses of the methylome and transcriptome to unravel sex differences in the perirenal fat from suckling lambs | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.3389/FGENE.2022.1035063 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/ Programa Estatal de I+D+i Orientada a los Retos de la Sociedad / RTI2018-093535-B-I00/ES/ ANALISIS DEL PAPEL DE LAS DE MARCAS EPIGENETICAS Y DE LA VARIABILIDAD GENOMICA EN LA REGULACION DE LA TRANSCRIPCION EN TEJIDOS DE INTERES PRODUCTIVO EN EL GANADO OVINO LECHERO// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1664-8021 | |
dc.journal.title | Frontiers in Genetics | es_ES |
dc.volume.number | 13 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 3309 Tecnología de Los Alimentos | es_ES |
dc.description.project | This research work was financially supported by the RTI2018-093535-B-I00 project funded by the “Agencia Estatal de Investigación” of the Spanish Ministry of Science and Innovation (Madrid, Spain). MA-G is funded by the Junta de Castilla y Leon fellowship. This research has used the high- performance computing resources of the Castilla y León Supercomputing Center (SCAYLE, www.scayle.es; León, Spain). PF is the beneficiary of a Maria Zambrano Grant of the University of Leon funding by the Ministry of Universities (Madrid, Spain) and financed by the European Union-Next Generation EU | es_ES |