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dc.contributorFacultad de Ciencias Biologicas y Ambientaleses_ES
dc.contributor.authorMalo Valenzuela, Aurelio F.
dc.contributor.authorMartínez Pastor, Felipe 
dc.contributor.authorAlaks, Glen
dc.contributor.authorDubach, Jean
dc.contributor.authorLacy, Robert C
dc.contributor.otherBiologia Celulares_ES
dc.date2010-10-01
dc.date.accessioned2019-04-14T23:23:44Z
dc.date.available2019-04-14T23:23:44Z
dc.date.issued2019-04-15
dc.identifier.citationBiology of Reproduction, 2010, vol. 83, n. 4es_ES
dc.identifier.otherhttps://academic.oup.com/biolreprod/article/83/4/540/2530167es_ES
dc.identifier.urihttp://hdl.handle.net/10612/10221
dc.descriptionP. 540–548es_ES
dc.description.abstractMice (Peromyscus leucopus noveboracensis) from a captive-breeding program were used to test the effects of three genetic breeding protocols (minimizing mean kinship [MK], random breeding, and selection for docility [DOC]) and inbreeding levels on sperm traits and fertility. Earlier, in generation 8, one DOC replicate went extinct because of poor reproductive success. By generation 10, spermatozoa from DOC mice had more acrosome and midpiece abnormalities, which were shown to be strong determinants of fertility, as well as lower sperm production and resistance to osmotic stress. In addition, determinants of fertility, including male and female components, were assessed in a comprehensive manner. Results showed that the probability (P) of siring litters is determined by sperm number, sperm viability, and midpiece and acrosome abnormalities; that the P of siring one versus two litters is determined by tail abnormalities; and that the total number of offspring is influenced by female size and proportion of normal sperm, showing the relative importance of different sperm traits on fertility. On average, males with 20% normal sperm sired one pup per litter, and males with 70% normal sperm sired eight pups per litter. Interestingly, the proportion of normal sperm was affected by docility but not by relatively low inbreeding. However, inbreeding depression in sperm motility was detected. In the MK group, inbreeding depression not only affected sperm motility but also fertility: An increase in the coefficient of inbreeding (f) of 0.03 reduced sperm motility by 30% and translated into an offspring reduction of three pups in second litters. A genetic load of 48 fecundity equivalents was calculated.es_ES
dc.languageenges_ES
dc.publisherOxford University Presses_ES
dc.subjectVeterinariaes_ES
dc.subject.otherConservation breedinges_ES
dc.subject.otherDocility, genetic adaptation to captivityes_ES
dc.subject.otherInbreeding depressiones_ES
dc.subject.otherMean kinshipes_ES
dc.subject.otherPeromyscus leucopuses_ES
dc.subject.otherReproductive successes_ES
dc.subject.otherTestosteronees_ES
dc.titleEffects of Genetic Captive-Breeding Protocols on Sperm Quality and Fertility in the White-Footed Mousees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.description.peerreviewedSIes_ES


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