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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorCastaño Labajo, Pablo
dc.contributor.authorFernández Fernández, Miguel
dc.contributor.authorRegidor Cerrillo, Javier
dc.contributor.authorFuertes Franco, Miguel 
dc.contributor.authorHorcajo Iglesias, María del Pilar
dc.contributor.authorFerré Pérez, Ignacio
dc.contributor.authorFerreras Estrada, María Del Carmen 
dc.contributor.authorOrtega Mora, Luis Miguel
dc.contributor.authorPérez Pérez, Valentín 
dc.contributor.authorBenavides Silván, Julio
dc.contributor.otherSanidad Animales_ES
dc.date2019-09-18
dc.date.accessioned2020-06-23T14:35:39Z
dc.date.available2020-06-23T14:35:39Z
dc.identifier.issn0928-4249
dc.identifier.otherhttps://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-019-0681-8es_ES
dc.identifier.urihttp://hdl.handle.net/10612/12273
dc.descriptionP. 1-9es_ES
dc.description.abstractAlthough it is known that gestation could infuence the clinical course of ovine toxoplasmosis, the precise efect of the term of gestation when sheep are infected are yet mostly unknown. The aim of this study was to evaluate the peripheral and placental immune responses developed in pregnant sheep after experimental infection with Toxoplasma gondiiat diferent times of gestation. Thirty‑six pregnant sheep were allocated in diferent groups, orally inocu‑lated with sporulated oocysts of T. gondiiat early, mid and late gestation and culled within 30 days post‑infection. The peripheral humoral and cytokine responses were evaluated, as well as the transcription of cytokines at the placenta. Serological analysis revealed that, regardless the term of gestation when infected, specifc IgG against T. gondiiwere detected from day 8 post‑infection and there was an early peripheral release of IFN‑γ at the frst week post‑infection followed by a short peak of IL10 and TNF‑α at the second week post‑infection. There were no signifcant diferences in this response between infected groups. At the placenta, a similar increase in transcription of IFN‑γ, and TNF‑α was found at the three terms of gestation, while IL‑4 increased mainly at the frst and second terms and IL‑10 transcription was higher at the last term. While these fndings show that both Th1 and Th2 cytokines play a key role in the patho‑genesis of ovine toxoplasmosis and that placental and peripheral immune responses do not closely correlate, there seems to be no clear modulation of these responses along the gestation.es_ES
dc.languageenges_ES
dc.publisherSpringeres_ES
dc.subjectInmunologíaes_ES
dc.subjectVeterinariaes_ES
dc.subject.otherGanado ovinoes_ES
dc.subject.otherToxoplasmosises_ES
dc.subject.otherEmbarazoes_ES
dc.subject.otherInmunología veterinariaes_ES
dc.titlePeripheral and placental immune responses in sheep after experimental infection with "Toxoplasma gondii" at the three terms of gestationes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doihttps://doi.org/10.1186/s13567-019-0681-8
dc.description.peerreviewedSIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn1297-9716
dc.journal.titleVeterinary Researches_ES
dc.volume.number50es_ES
dc.issue.number66es_ES
dc.page.initial1es_ES
dc.page.final9es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.unesco2401.11 Patología Animales_ES


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