• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
Consorcio BUCLE Recolector
  • Contact Us
  • Send Feedback
  • Enlaces y accesos
    • Derechos de autor
    • Políticas
    • Guía de autoarchivo
    • FAQ y ayuda
    • La ULE y el Acceso Abierto
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Repositorio
    Institucional
    Abierto

    Consorcio BUCLE Recolector

    Browse

    All of BULERIACommunities and CollectionsAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulaciónThis CollectionAuthorsDirectoresTitlesSubjectsFacultad/CentroÁrea de conocimientoFecha de creación/publicaciónTitulación

    My Account

    Login

    Statistics

    View Usage Statistics

    Otros enlaces

    View Item 
    •   BULERIA Home
    • Scientific Production
    • Untitled
    • View Item
    •   BULERIA Home
    • Scientific Production
    • Untitled
    • View Item

    Compartir

    Export

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Título
    Hepatic Nrf2 expression is altered by quercetin supplementation in X-irradiated rats
    Autor
    Marina Hernández, Raquel
    González Sevilla, María FranciscaAutoridad Buleria
    Ferreras Estrada, María Del CarmenAutoridad Buleria
    Costilla García, Serafín Marcos
    Barrio Lera, Juan PabloAutoridad Buleria
    Facultad/Centro
    Facultad de Veterinaria
    Área de conocimiento
    Sanidad Animal
    Título de la revista
    Molecular Medicine Reports
    Número de la revista
    1
    Editor
    Spandidos Publications
    Fecha
    2015-01-01
    ISSN
    1791-2997
    Abstract
    Whole‑body irradiation has been associated with liver function alterations. Ionizing radiation exposure increases oxidative stress and antioxidants can activate transcription of antioxidant target genes. In the present study, modifications of the liver antioxidant system were evaluated at 7 and 30 days following sub‑lethal whole‑body X‑irradiation in male Wistar rats, which were intragastrically supplemented with quercetin or control solvent for 4 days prior to and 6 days following irradiation. Animal groups were as follows: CS, control, solvent‑supplemented; CQ, control, quercetin‑supplemented; RS, irradiated, solvent‑supplemented; and RQ, irradiated, quercetin‑supplemented. After 7 days, liver tissue from RS animals demonstrated marked hydropic panlobular degeneration with Mallory bodies in ballooning hepatocytes. These changes were mostly reversed in RQ rats. Lipid peroxidation in addition to copper/zinc superoxide dismutase (Cu/Zn‑SOD), nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) and Kelch‑like ECH‑associated protein 1 (Keap1) protein expression levels were all increased by X‑irradiation, but significantly decreased by quercetin supplementation. Catalase (CAT) and NAD(P)H: quinone oxidoreductase 1 (NQO1) expression levels remained high in irradiated rats regardless of quercetin supplementation. After 30 days, the liver from RS animals had small portal infiltrates and diffuse cytoplasmic vacuolization, with reduced lipid peroxidation and reduced expression levels of CAT, NQO1, Nrf2 and Keap1, but consistently elevated Cu/Zn‑SOD expression. RQ animals indicated reduced expression levels of Nrf2 and Keap1 30 days after irradiation. The present study demonstrated a quercetin‑induced reduction of the oxidative stress‑associated increase in Nrf2 expression that may be useful for preventing cancer cell survival in response to ionizing radiation exposure.
    Materia
    Sanidad animal
    Palabras clave
    Ratas
    Quercetina
    Rayos X
    Radiación
    Peer review
    SI
    URI
    http://hdl.handle.net/10612/12363
    DOI
    https://doi.org/10.3892/mmr.2014.2741
    Versión del editor
    https://www.spandidos-publications.com/10.3892/mmr.2014.2741
    Collections
    • Untitled [2807]
    Show full item record
    Files in this item
    Nombre:
    Hepatic Nrf2 expression is altered by quercetin supplementation in X.irradiated rats.pdf
    Tamaño:
    997.7 xmlui.dri2xhtml.METS-1.0.size-kilobytes
    Formato:
    Adobe PDF
    Descripción:
    artículo principal
    Thumbnail
    FilesOpen