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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorCobo Díaz, José Francisco
dc.contributor.authorGonzález del Río, Paloma
dc.contributor.authorÁlvarez Ordóñez, Avelino 
dc.contributor.otherAlgebraes_ES
dc.date2021-07-04
dc.date.accessioned2021-08-19T13:23:03Z
dc.date.available2021-08-19T13:23:03Z
dc.identifier.otherhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.662144/fulles_ES
dc.identifier.urihttp://hdl.handle.net/10612/13371
dc.description-es_ES
dc.description.abstractCampylobacter spp. are the most frequent agent of human gastroenteritis worldwide, and the spread of multidrug-resistant strains makes the clinical treatment difficult. The current study presents the resistome analysis of 39,798 Campylobacter jejuni and 11,920 Campylobacter coli genomes available in public repositories. Determinants of resistance to β-lactams (Be) and tetracyclines (Te) were the most frequent for both species, with resistance to quinolones (Qu) as the third most important on C. jejuni and to aminoglycosides (Am) on C. coli. Moreover, resistance to Te, Qu, and Am was frequently found in co-occurrence with resistance to other antibiotic families. Geographical differences on clonal complexes distribution were found for C. jejuni and on resistome genotypes for both C. jejuni and C. coli species. Attending to the resistome patterns by isolation source, three main clusters of genomes were found on C. jejuni genomes at antimicrobial resistance gene level. The first cluster was formed by genomes from human, food production animals (e.g., sheep, cow, and chicken), and food (e.g., dairy products) isolates. The higher incidence of tet(O), associated with tetracycline resistance, and the gyrA (T86I) single-nucleotide polymorphism (SNP), associated with quinolone resistance, among genomes from this cluster could be due to the intense use of these antibiotics in veterinary and human clinical settings. Similarly, a high incidence of tet(O) genes of C. coli genomes from pig, cow, and turkey was found. Moreover, the cluster based on resistome patterns formed by C. jejuni and C. coli genomes of human, turkey, and chicken origin is in agreement with previous observations reporting chicken or poultry-related environments as the main source of human campylobacteriosis infections. Most clonal complexes (CCs) associated with chicken host specialization (e.g., ST-354, ST-573, ST-464, and ST-446) were the CCs with the highest prevalence of determinants of resistance to Be, Qu, and Te. Finally, a clear trend toward an increase in the occurrence of Te and Qu resistance determinants on C. jejuni, linked to the spread of the co-occurrence of the bla OXA−61 and tet(O)-tet(O/W/O) genes and the gyrA (T86I) SNP, was found from 2001 to date in Europe.es_ES
dc.languageenges_ES
dc.subjectGenéticaes_ES
dc.subject.otherCampylobacter colies_ES
dc.subject.otherResistomees_ES
dc.subject.otherWhole genome sequencinges_ES
dc.subject.otherHost specializationes_ES
dc.subject.otherLivestock and human sourceses_ES
dc.titleWhole Resistome Analysis in Campylobacter jejuni and C. coli Genomes Available in Public Repositorieses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.3389/fmicb.2021.662144
dc.description.peerreviewedSIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/818368/EUes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn1664-302X
dc.journal.titleFrontiers in Microbiologyes_ES
dc.volume.number12es_ES
dc.page.initial662144es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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