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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Juárez‐Fernández, María | |
dc.contributor.author | Goikoetxea‐Usandizaga, Naroa | |
dc.contributor.author | Porras, David | |
dc.contributor.author | García Mediavilla, María Victoria | |
dc.contributor.author | Bravo, Miren | |
dc.contributor.author | Serrano‐Maciá, Marina | |
dc.contributor.author | Simón, Jorge | |
dc.contributor.author | Delgado, Teresa C. | |
dc.contributor.author | Lachiondo‐Ortega, Sofía | |
dc.contributor.author | Martínez‐Flórez, Susana | |
dc.contributor.author | Lorenzo, Óscar | |
dc.contributor.author | Rincón, Mercedes | |
dc.contributor.author | Varela‐Rey, Marta | |
dc.contributor.author | Abecia, Leticia | |
dc.contributor.author | Rodríguez, Héctor | |
dc.contributor.author | Anguita, Juan | |
dc.contributor.author | Nistal González, Maria Esther | |
dc.contributor.author | Martínez‐Chantar, María Luz | |
dc.contributor.author | Sánchez Campos, Sonia | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2022 | |
dc.date.accessioned | 2022-12-12T10:45:17Z | |
dc.date.available | 2022-12-12T10:45:17Z | |
dc.identifier.citation | Juárez-Fernández, M., Goikoetxea-Usandizaga, N., Porras, D., García-Mediavilla, M. V., Bravo, M., Serrano-Maciá, M., Simón, J., Delgado, T. C., Lachiondo-Ortega, S., Martínez-Flórez, S., Lorenzo, Ó., Rincón, M., Varela-Rey, M., Abecia, L., Rodríguez, H., Anguita, J., Nistal, E., Martínez-Chantar, M. L., & Sánchez-Campos, S. (2022). Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression. Hepatology. https://doi.org/10.1002/HEP.32705 | es_ES |
dc.identifier.issn | 0270-9139 | |
dc.identifier.uri | http://hdl.handle.net/10612/15320 | |
dc.description.abstract | [EN] Background and Aims: Recent studies suggest that mitochondrial dysfunction promotes progression to NASH by aggravating the gut-liver status. However, the underlying mechanism remains unclear. Herein, we hypothesized that enhanced mitochondrial activity might reshape a specific microbiota signature that, when transferred to germ-free (GF) mice, could delay NASH progression. Approach and Results: Wild-type and methylation-controlled J protein knockout (MCJ-KO) mice were fed for 6 weeks with either control or a choline-deficient, L-amino acid–defined, high-fat diet (CDA-HFD). One mouse of each group acted as a donor of cecal microbiota to GF mice, who also underwent the CDA-HFD model for 3 weeks. Hepatic injury, intestinal barrier, gut microbiome, and the associated fecal metabolome were then studied. Following 6 weeks of CDA-HFD, the absence of methylation-controlled J protein, an inhibitor of mitochondrial complex I activity, reduced hepatic injury and improved gut-liver axis in an aggressive NASH dietary model. This effect was transferred to GF mice through cecal microbiota transplantation. We suggest that the specific microbiota profile of MCJ-KO, characterized by an increase in the fecal relative abundance of Dorea and Oscillospira genera and a reduction in AF12, Allboaculum, and [Ruminococcus], exerted protective actions through enhancing short-chain fatty acids, nicotinamide adenine dinucleotide (NAD+) metabolism, and sirtuin activity, subsequently increasing fatty acid oxidation in GF mice. Importantly, we identified Dorea genus as one of the main modulators of this microbiota-dependent protective phenotype. Conclusions: Overall, we provide evidence for the relevance of mitochondria–microbiota interplay during NASH and that targeting it could be a valuable therapeutic approach. | es_ES |
dc.language | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | Mitochondrial dysfunction | es_ES |
dc.subject.other | Nonalcoholic Steatohepatitis (NASH) | es_ES |
dc.title | Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1002/hep.32705 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/BFU2017- 87960- R/ES/EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/PID2020- 120363RB- I/ES/MICROBIOTA INTESTINAL Y DAÑO HEPATICO POR FARMACOS (DILI). TRANSFERENCIA DE PERFILES ESPECIFICOS Y MODULACION DE MICROBIOTA EN MODELOS EXPERIMENTALES DE DILI POR CLAVULANATO | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/PID2020-117116RB-I00/ES/DESVELANDO EL PAPEL DE LA NEDILACION EN EL ESTRES NUTRICIONAL | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1527-3350 | |
dc.journal.title | Hepatology | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es_ES |
dc.subject.unesco | 2411 Fisiología Humana | es_ES |
dc.description.project | Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCLE |
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