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Título
Influence of a temporary restriction of dietary protein in prepubertal ewe lambs on first lactation milk traits and response to a mammary gland inflammatory challenge
Autor
Facultad/Centro
Área de conocimiento
Título de la revista
Research in Veterinary Science
Datos de la obra
Pelayo, R., Marina, H., Suárez-Vega, A., Hervás, G., Esteban-Blanco, C., Gausseres, B., Foucras, G., Arranz, J. J., & Gutiérrez-Gil, B. (2023). Influence of a temporary restriction of dietary protein in prepubertal ewe lambs on first lactation milk traits and response to a mammary gland inflammatory challenge. Research in Veterinary Science, 159, 57–65. https://doi.org/10.1016/j.rvsc.2023.04.006
Editor
Elsevier
Fecha
2023
ISSN
0034-5288
Abstract
[EN] This study evaluated the influence of a temporary nutritional protein restriction (NPR) performed, under commercial conditions, in prepubertal female lambs on first lactation milk production traits and the inflammatory response triggered by an inflammatory challenge of the. From 40 Assaf female lambs, we defined a control group (C n = 20), which received a standard diet for replacement lambs and the NPR group (n = 20), which received the same diet but without soybean meal between 3 and 5 months of age. About 150 days after lambing, 24 of these ewes (13 NPR, 11C) were subjected to an intramammary infusion of E. coli lipopolysaccharide (LPS). Our dynamic study identified indicator traits of local (SCC) and systemic (rectal Ta, IL-6, CXCL8, IL-10, IL-36RA, VEGF-A) response to the LPS challenge. The NPR did not show significant effects on milk production traits and did not affect the SCC and rectal Ta after the LPS challenge. However, the NPR had a significant influence on 8 of the 14 plasma biomarkers analysed, in all the cases with higher relative values in the C group. The effects observed on VEGF-A (involved in vasculogenesis during mammary gland development and vascular permeability) and IL-10 (a regulatory cytokine classically known by its anti-inflammatory action) are the most remarkable to explain the differences found between groups. Whereas further studies should be undertaken to confirm these results, our findings are of interest considering the current concern about the future world's demand for protein and the need for animal production systems to evolve toward sustainability.
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ID proyecto
- info:eu-repo/grantAgreement/EC/H2020/772787
- info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/RTI2018-093535-B-I00/ES/ANALISIS DEL PAPEL DE LAS DE MARCAS EPIGENETICAS Y DE LA VARIABILIDAD GENOMICA EN LA REGULACION DE LA TRANSCRIPCION EN TEJIDOS DE INTERES PRODUCTIVO EN EL GANADO OVINO LECHERO
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