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dc.contributorFacultad de Ciencias de la Saludes_ES
dc.contributor.authorMauriz García, Elba 
dc.contributor.authorLechuga, Laura María
dc.contributor.otherQuimica Analiticaes_ES
dc.date2021
dc.date.accessioned2024-01-30T08:38:33Z
dc.date.available2024-01-30T08:38:33Z
dc.identifier.citationMauriz E, Lechuga LM. Current Trends in SPR Biosensing of SARS-CoV-2 Entry Inhibitors. Chemosensors. 2021; 9(12):330. https://doi.org/10.3390/chemosensors9120330es_ES
dc.identifier.urihttps://hdl.handle.net/10612/17902
dc.description.abstractThe emerging risk of viral diseases has triggered the search for preventive and therapeutic agents. Since the beginning of the COVID-19 pandemic, greater efforts have been devoted to investigating virus entry mechanisms into host cells. The feasibility of plasmonic sensing technologies for screening interactions of small molecules in real time, while providing the pharmacokinetic drug profiling of potential antiviral compounds, offers an advantageous approach over other biophysical methods. This review summarizes recent advancements in the drug discovery process of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) inhibitors using Surface Plasmon Resonance (SPR) biosensors. A variety of SPR assay formats are discussed according to the binding kinetics and drug efficacies of both natural products and repurposed drugs. Special attention has been given to the targeting of antiviral agents that block the receptor binding domain of the spike protein (RBD-S) and the main protease (3CLpro) of SARS-CoV-2. The functionality of plasmonic biosensors for high-throughput screening of entry virus inhibitors was also reviewed taking into account experimental parameters (binding affinities, selectivity, stability), potential limitations and future applications.es_ES
dc.languageenges_ES
dc.publisherMDPIes_ES
dc.subjectQuímicaes_ES
dc.subject.otherPlasmonices_ES
dc.subject.otherSPR biosensores_ES
dc.subject.otherViral diagnosticses_ES
dc.subject.otherVirus entry inhibitorses_ES
dc.subject.otherDrug screeninges_ES
dc.subject.otherAntiviral agentses_ES
dc.subject.otherSARS-CoV-2es_ES
dc.subject.otherCOVID-19es_ES
dc.titleCurrent Trends in SPR Biosensing of SARS-CoV-2 Entry Inhibitorses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.3390/chemosensors9120330
dc.description.peerreviewedSIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn2227-9040
dc.journal.titleChemosensorses_ES
dc.volume.number9es_ES
dc.issue.number12es_ES
dc.page.initial330es_ES
dc.page.final355es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES


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