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dc.contributor | Facultad de Veterinaria | es_ES |
dc.contributor.author | Porras Sanabria, David | |
dc.contributor.author | Nistal González, Maria Esther | |
dc.contributor.author | Martínez Flórez, Susana | |
dc.contributor.author | Olcoz Goñi, José Luis | |
dc.contributor.author | Jover Atienza, Ramiro | |
dc.contributor.author | Jorquera, F. | |
dc.contributor.author | González Gallego, Javier | |
dc.contributor.author | García Mediavilla, María Victoria | |
dc.contributor.author | Sánchez Campos, Sonia | |
dc.contributor.other | Fisiologia | es_ES |
dc.date | 2019 | |
dc.date.accessioned | 2024-01-30T11:50:56Z | |
dc.date.available | 2024-01-30T11:50:56Z | |
dc.identifier.citation | Porras, D., Nistal González, E., Martínez-Flórez, S., Olcoz, J. L., Jover, R., Jorquera, F., González-Gallego, J., García-Mediavilla, M. V., & Sánchez-Campos, S. (2019). Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High-Fat Diet Determine Non-Alcoholic Fatty Liver Disease Development in Germ-Free Mice. Molecular Nutrition and Food Research, 63(8). https://doi.org/10.1002/MNFR.201800930 | es_ES |
dc.identifier.issn | 1613-4125 | |
dc.identifier.other | https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201800930 | es_ES |
dc.identifier.uri | https://hdl.handle.net/10612/17922 | |
dc.description.abstract | [EN] Scope: Modulation of intestinal microbiota has emerged as a new therapeutic approach for non-alcoholic fatty liver disease (NAFLD). Herein, it is addressed whether gut microbiota modulation by quercetin and intestinal microbiota transplantation can influence NAFLD development. Methods and results: Gut microbiota donor mice are selected according to their response to high-fat diet (HFD) and quercetin in terms of obesity and NAFLD-related biomarkers. Germ-free recipients displayed metabolic phenotypic differences derived from interactions between microbiota transplanted, diets, and quercetin. Based on the evaluation of hallmark characteristics of NAFLD, it is found that gut microbiota transplantation from the HFD-non-responder donor and the HFD-fed donor with the highest response to quercetin results in a protective phenotype against HFD-induced NAFLD, in a mechanism that involves gut–liver axis alteration blockage in these receivers. Gut microbiota from the HFD-responder donor predisposed transplanted germ-free mice to NAFLD. Divergent protective and deleterious metabolic phenotypes exhibited are related to definite microbial profiles in recipients, highlighting the predominant role of Akkermansia genus in the protection from obesity-associated NAFLD development. Conclusions: The results provide scientific support for the prebiotic capacity of quercetin and the transfer of established metabolic profiles through gut microbiota transplantation as a protective strategy against the development of obesity-related NAFLD | es_ES |
dc.language | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fisiología | es_ES |
dc.subject.other | Akkermansia spp | es_ES |
dc.subject.other | Flavonoids | es_ES |
dc.subject.other | Gut microbiota transplantation | es_ES |
dc.subject.other | Gut-liver axis | es_ES |
dc.subject.other | Nonalcoholic fatty liver disease | es_ES |
dc.title | Functional Interactions between Gut Microbiota Transplantation, Quercetin, and High‐Fat Diet Determine Non‐Alcoholic Fatty Liver Disease Development in Germ‐Free Mice | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.identifier.doi | 10.1002/MNFR.201800930 | |
dc.description.peerreviewed | SI | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/BFU2013-48141-R/ES/ ESTUDIO DEL EFECTO DEL TRATAMIENTO CON QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL EN MODELOS EXPERIMENTALES DE HIGADO GRASO NO ALCOHOLICO// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Programa Estatal de I+D+i Orientada a los Retos de la Sociedad/BFU2017-87960-R/ES/EFECTO DEL EJERCICIO FISICO Y QUERCETINA Y DEL TRASPLANTE DE MICROBIOTA INTESTINAL PROTECTORA O PREDISPONENTE ADICIONADA CON AKKERMANSIA MUCINIPHILA EN MODELOS DE NAFLD// | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/Junta de Castilla y León LE135U13/ES/EFECTO DE FLAVONOIDES SOBRE EL DESARROLLO DE ESTEATOSIS, ESTEATOHEPATITIS Y HEPATOCARCINOMA EN MODELOS IN VIVO E IN VITRO DE NAFLD// | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es_ES |
dc.identifier.essn | 1613-4133 | |
dc.journal.title | Molecular Nutrition & Food Research | es_ES |
dc.volume.number | 63 | es_ES |
dc.issue.number | 8 | es_ES |
dc.page.initial | 1800930 | es_ES |
dc.type.hasVersion | info:eu-repo/semantics/submittedVersion | es_ES |
dc.subject.unesco | 2411 Fisiología Humana | es_ES |
dc.description.project | M.V.G.M. and S.S.C. share senior authorship. D.P. and E.N. made equal contribution to the study. D.P., E.N., S.M.F., M.V.G.M., and S.S.C. performed most of the experiments. J.L.O. and F.J. performed statistical analysis. R.J. and J.G.G. assisted for in vivo models. S.S.C. designed the experiments and supervised the study. All the authors wrote the manuscript. The authors thank Drs. Gérard and Rabot, from MICALIS Institute (INRA), for providing germ-free mice. This work was supported by grants from Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional (FEDER) (BFU2013-48141-R, BFU2017-87960-R), Junta de Castilla y León (LE135U13, GRS 1428/A/16), Junta de Castilla y León and FEDER, (LE063U16), and IIS Hospital La Fe (2017_0092_PP). D.P. was supported by a fellowship from Junta de Castilla y León co-financed by the European Social Fund. E.N. was supported by Fundación de Investigación Sanitaria of León. M.V.G.M. was supported by CIBERehd contracts. CIBERehd is funded by the Instituto de Salud Carlos III, Spain | es_ES |
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