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dc.contributorFacultad de Veterinariaes_ES
dc.contributor.authorDos Santos, Fernanda Caroline
dc.contributor.authorDiniz Peixoto, Maria Gabriela Campolina
dc.contributor.authorDe Souza Fonseca, Pablo Augusto
dc.contributor.authorÁvila Pires, Maria de Fátima
dc.contributor.authorVieira Ventura, Ricardo
dc.contributor.authorDa Cruz Rosse, Izinara
dc.contributor.authorTomita Bruneli, Frank Angelo
dc.contributor.authorMachado, Marco Antonio
dc.contributor.authorSantos Carvalho, Maria Raquel
dc.contributor.otherProducción Animales_ES
dc.date2017
dc.date.accessioned2024-01-30T13:10:29Z
dc.date.available2024-01-30T13:10:29Z
dc.identifier.citationDos Santos, F. C., Peixoto, M. G. C. D., Fonseca, P. A. D. S., Pires, M. D. F. Á., Ventura, R. V., Rosse, I. D. C., ... & Carvalho, M. R. S. (2017). Identification of candidate genes for reactivity in guzerat (Bos indicus) cattle: a genome-wide association study. PLoS One, 12(1), e0169163.es_ES
dc.identifier.otherhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169163es_ES
dc.identifier.urihttps://hdl.handle.net/10612/17928
dc.description.abstract[EN] Temperament is fundamental to animal production due to its direct influence on the animalherdsman relationship. When compared to calm animals, the aggressive, anxious or fearful ones exhibit less weight gain, lower reproductive efficiency, decreased milk production and higher herd maintenance costs, all of which contribute to reduced profits. However, temperament is a trait that is complex and difficult to assess. Recently, a new quantitative system, REATEST®, for assessing reactivity, a phenotype of temperament, was developed. Herein, we describe the results of a Genome-wide association study for reactivity, assessed using REATEST® with a sample of 754 females from five dual-purpose (milk and meat production) Guzerat (Bos indicus) herds. Genotyping was performed using a 50k SNP chip and a twostep mixed model approach (Grammar-Gamma) with a one-by-one marker regression was used to identify QTLs. QTLs for reactivity were identified on chromosomes BTA1, BTA5, BTA14, and BTA25. Five intronic and two intergenic markers were significantly associated with reactivity. POU1F1, DRD3, VWA3A, ZBTB20, EPHA6, SNRPF and NTN4 were identified as candidate genes. Previous QTL reports for temperament traits, covering areas surrounding the SNPs/genes identified here, further corroborate these associations. The seven genes identified in the present study explain 20.5% of reactivity variance and give a better understanding of temperament biology. Introductiones_ES
dc.languageenges_ES
dc.publisherPloses_ES
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGenéticaes_ES
dc.subject.otherGWASes_ES
dc.subject.otherTemperamentes_ES
dc.subject.otherCattlees_ES
dc.titleIdentification of Candidate Genes for Reactivity in Guzerat (Bos indicus) Cattle: A Genome-Wide Association Studyes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.identifier.doi10.1371/journal.pone.0169163
dc.description.peerreviewedSIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.identifier.essn1932-6203
dc.journal.titlePLOS ONEes_ES
dc.volume.number12es_ES
dc.issue.number1es_ES
dc.page.initiale0169163es_ES
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones_ES
dc.subject.unesco3109 Ciencias Veterinariases_ES
dc.subject.unesco3109.02 Genéticaes_ES
dc.description.projectWe thank the farmers, who allowed the development of this project in their facilities. We thank to Mr. Peter Laspina for performing language review and for the valuable comments. This study was supported by Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Empresa Brasileira de Pesquisa Agropecuária (Embrapa). Maria Gabriela Campolina Diniz Peixoto was supported by the Fapemig—CVZ APQ 01353 e CVZ APQ 3182–5.04/07. MRSC has a fellowship from the CNPq– 307975/2010-0 and was supported by CNPq– 312068/2015-8 and 481018/2008-5 projects. MGCDP, RVV, MAM have fellowships from FAPEMIG. PASF has CNPq fellowship, FCS and ICR have CAPES fellowships.es_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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